Dolutegravir

'The chemical name of dolutegravir sodium is sodium (4R,12aS)-9-{[(2,4-difluorophenyl)methyl]carbamoyl}- 4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazin-7- olate. Dolutegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and children aged 12 years and older and weighing at least 40 kg.'

Brands
Adult Dose
Neonatal
Paedriatic
Dose: 0 to 50 mg
Single Dose: 25 (25)
Frequency: As recommended.
Route: PO
Instructions: pediatric patients aged 12 years and older and weighing at least 40 kg
Characteristics
. It is of Synthetic origin. It belongs to Antiviral Agents pharmacological group on the basis of mechanism of action. The Molecular Weight of Dolutegravir is 441.36.
Contraindications
Dolutegravir
Effects
The symptomatic adverse reactions produced by Dolutegravir are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Insomnia.
Indications
Dolutegravir is primarily indicated in conditions like HIV infection in combination with other antiretroviral drugs.
Interactions
No data regarding the interactions of Dolutegravir was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tablet Store Between 15°C-30°C.
Warnings
Hypersensitivity reactions characterized by rash, constitutional findings, and sometimes organ dysfunction, including liver injury.Effects on Serum Liver Biochemistries in Patients With Hepatitis B or C 51 Co-infection, Fat redistribution, immune reconstitution syndrome. caution should be taken in all these conditions.
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