Afatinib

Afatinib is a tyrosine kinase inhibitor which is a 4-anilinoquinazoline. Afatinib is presented as the dimaleate salt, with the chemical name 2-butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]­7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-,(2E)-, (2Z)-2-butenedioate (1:2). It is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to quinazolinamines. It belongs to Tyrosine kinase inhibitor pharmacological group on the basis of mechanism of action. The Molecular Weight of Afatinib is 718.10.
Contraindications
Afatinib
Effects
The symptomatic adverse reactions produced by Afatinib are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Stomatitis, Dry skin, Dermatitis, Acneform, Loss of appetite, Paronychia, Pruritis, Rash.
Indications
Afatinib is primarily indicated in conditions like Non small cell lung cancer.
Interactions
No data regarding the interactions of Afatinib was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tablet Store Between 15°C-30°C. Protect from Sunlight and Moisture.
Warnings
diarrhea,bullous and exfoliative skin disorders, interstitial lung disease, hepatic toxicity, keratitis, embryofetal toxicity. caution should be taken in all these conditions.
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