Dabrafenib

Dabrafenib mesylate is a kinase inhibitor. The chemical name for dabrafenib mesylate is N-{3- [5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6- difluorobenzene sulfonamide, methanesulfonate salt. it is used for the treatment of patients with unresectable or metastatic melanoma with braf V600E mutation.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to phenylthiazoles. It belongs to Protein kinase inhibitor pharmacological group on the basis of mechanism of action. The Molecular Weight of Dabrafenib is 615.68.
Contraindications
Dabrafenib
Effects
The symptomatic adverse reactions produced by Dabrafenib are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Nausea, Vomiting, Alopecia, Myalgia, Constipation, Chills, Cough, Arthralgia, Pyrexia, Alopecia, Rash, hyperkeratosis, papilloma, palmae plantar erythrodysesthesia syndrome, pyrexia, night sweats, myalgia.
Indications
Dabrafenib is primarily indicated in conditions like Metastatic melanoma, Metastatic melanoma.
Interactions
No data regarding the interactions of Dabrafenib was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Capsule Store Below 30°C.
Warnings
new malignancies (cutaneous and non cutaneous), tumor promotion in BRAF wild-type melanoma,Hemorrhage, venous Thromboembolism, cardiomyopathy, ocular toxicities, serious febrile reactions, serious skin toxicity, hyperglycemia, glucose -6 -phosphate dehydrogenase deficiency, embryofetal toxicity,
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