Sorafenib

Sorafenib as sorafenib tosylate is an antineoplastic agent and shows its activity by kinase inhibitor.Sorafenib tosylate has the chemical name 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)N2methylpyridine-2-carboxamide 4-methylbenzenesulfonate

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. It belongs to Protein kinase inhibitor pharmacological group on the basis of mechanism of action. The Molecular Weight of Sorafenib is 637.00.
Contraindications
Sorafenib
Effects
The severe or irreversible adverse effects of Sorafenib, which give rise to further complications include Hypertension, Hemorrhage, Myocardial infarction, gastrointestinal perforation, drug induced hepatitis.The symptomatic adverse reactions produced by Sorafenib are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fatigue, Nausea, Alopecia, Anorexia, Diarrhea, Abdominal pain, Weight loss, Alopecia, Rash.
Indications
Sorafenib is primarily indicated in conditions like Liver carcinoma, Renal carcinoma, Thyroid cancer.
Interactions
No data regarding the interactions of Sorafenib was found.
Interfrence
HypophosphataemiaIncreased LipaseIncreased amylasehypocalcaemia
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tablet Store at room temperature, . Refrigeration and Freezing is not recommended. Protect from Sunlight.
Warnings
Dermatological toxicities, Haemorrhage, Cardiac Ischemia and/or infraction, QT interval prolongation, Gastrointestinal perforation, wound healing complications, elderly patient, hepatic impairment, warfarin co administration
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