Dextropropoxyphene

Dextropropoxyphene is a weak narcotic anagesic (reliefes the pian with unconsciousness) and used in the management of moderate pain. Commonly Dextropropoxyphene is given in combination with paracetamol.


Adult Dose
Dose: 65 mg
Single Dose: 65 (65)
Frequency: 4 hourly
Route: PO
Instructions: Maximum dose 390 mg/day. Frequency may be increased to 8 times if needed.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Opioid. It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Dextropropoxyphene is 375.90. Its pKa is 6.3.
Contraindications
Dextropropoxyphene is contraindicated in conditions like Psychosis,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Dextropropoxyphene, which give rise to further complications include Sinus tachycardia, Hypotension, Hypotension, Orthostatic hypotension, Seizures, Dependence, Cholestasis, Psychosis, Sinus bradycardia, Syncope, Decreased libido, Biliary obstruction.Dextropropoxyphene produces potentially life-threatening effects which include Convulsions. which are responsible for the discontinuation of Dextropropoxyphene therapy.The signs and symptoms that are produced after the acute overdosage of Dextropropoxyphene include Hypotension, Cardiac arrhythmias, Pulmonary edema, Convulsions, Coma, Drowsiness, Respiratory depression, Ataxia, Miosis, Circulatory collapse.The symptomatic adverse reactions produced by Dextropropoxyphene are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Vomiting, Anorexia, Restlessness, Palpitation, Constipation, Abdominal pain, Skin rashes, Blurred vision, Confusion, Pruritus, Jaundice, Sedation, Malaise, Diaphoresis, Flushing, Elevation of liver enzymes, Dysphoria, Vision disturbances, Hyponatremia, Urinary RetentionX, Confusion, Skin rashes, dizziness.
Indications
Dextropropoxyphene is primarily indicated in conditions like Mild to moderate pain, Opioid addiction.
Interactions
Dextropropoxyphene is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCarbamazepineEffects of Carbamazepine enhanced by Dextropropoxyphene.MajorFosphenytoinPhenobarbitonePhenytoin (Na)RitonavirWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 25°C.
Warnings
Dextropropexyphene should be used with caution in patients with respiratory depression, alcoholism, convulsive disorder, head injuries, hypothyroidism, asthma, impaired kidney or liver function. It should be used with great care in infants or neonates. Patient should observe caution while driving or performing tasks requiring alertness, because it may produce drowsiness.
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