DENOSUMAB

Denosumab is a human monoclonal antibody (IgG2) that targets and bind with hiogh affinity and specificity to RANK-L, Preventing activation of its receptors, rank, on the surface of osteolast precursorss and osteoclast, in this way it inhibits ostoclast formation, function and survival, thereby decreasing bone resorption in cortical and trabecular bone, it is used for the treatment of osteoporosis. in post menopausal women. and in men with prostate cancer reciveing hormone ablation.

Brands
Adult Dose
Dose: 60 mg
Single Dose: 60 (60)
Frequency: As recommended.
Route: S/C
Instructions: given every 6 months
Neonatal
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
It belongs to Human mono clobal antibody pharmacological group on the basis of mechanism of action.
Contraindications
DENOSUMAB is contraindicated in conditions like Hypocalcaemia,Hypersensitivity reactions.
Effects
The symptomatic adverse reactions produced by DENOSUMAB are more or less tolerable and if they become severe, they can be treated symptomatically, these include Constipation, Rashes, Cataract, Pain in upper & lower extremities, Eczema, Sciatica.
Indications
DENOSUMAB is primarily indicated in conditions like Bone metastasis, Myeloma, Osteoporosis in postmenopausal women, Rheumatoid arthritis.
Interactions
No data regarding the interactions of DENOSUMAB was found.
Interfrence
Risks
Drug should not be given to Paediatrics, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
inj
Warnings
Good oral hygine practice should be maintained during treatment with denosumab, for patient who develop osteonecrosis of jaws while on Denosumab therapy, dental surgery may excerbate the condition. It sholud not be given to patient with fructose intolerance. use with caution in patient with renal impariment or creatine clearence less than 30ml/min.
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