Dose: 500 to 500 ug
Single Dose: 500 (500)
Frequency: 24 hourly
Route: PO
Instructions:

. It is of Synthetic origin. It belongs to PDE4 Inhibitor pharmacological group on the basis of mechanism of action.

Roflumilast is contraindicated in conditions like Hypersensitivity,Hepatic impairment.

Roflumilast produces potentially life-threatening effects which include Suicidal ideation. which are responsible for the discontinuation of Roflumilast therapy.The signs and symptoms that are produced after the acute overdosage of Roflumilast include Palpitations, Dizziness, Headache, GI disturbances, aterial hypotension.The symptomatic adverse reactions produced by Roflumilast are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Diarrhea, Insomnia, Abdominal pain, Decreased appetite, Weight loss.

Roflumilast is primarily indicated in conditions like Chronic bronchitis, Chronic obstructive pulmonary disease.

Roflumilast is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCladribineEnoxacinRoflumilast interacts with dual CYP34A/1A2 INHIBITOR like enoxacin and cimetidine where it result in an 59% increase in the roflumilast PDE4 inhibitory effect.ErythromycinRoflumilast interacts with CYP34A Inhibitor like erythomycin, ketoconazole which results in the roflumilast 9% total inhibitory activity of PDE4.Fluvoxamine (Maleate)Roflumilast interacts with CYP1A2 INHIBITOR like fluvoxamine where it result in an 59% increase in the roflumilast PDE4 inhibitory effect.Phenobarbital Sodiumroflumilast interacts with CPY450 inducers like phenobarbital, carbamezapine, phenytonin which reduce its 60% inhibitory effect on PDE4.reduce efficacyRiociguatClinical experience with co-administration is limitedTheophyllineRoflumilast when co administer with theophylline reult in 8% incerase in the roflumilast PDE4 Inhibitory effect. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Not to be use as a rescue medicinal product for acute bronchospams, should not be gien in patient with CHF, Risk of psychiatric disorder, not recomended with theophylline, patient with glastose intolerance should not use it, patient should reduce smoking, in case of clinically decrease weight lose treatment should be stoped.