Dose: 300 to 300 mg
Single Dose: 300 (300)
Frequency: 24 hourly
Route: PO
Instructions: Take with or without food at about the same time each day. Starting dose is 200 mg in patients with renal impairment.

. It is of Synthetic origin. It belongs to Protein kinase inhibitor pharmacological group on the basis of mechanism of action.

Vandetanib is contraindicated in conditions like Hypersensitivity,Lactation,QTc prolongation,Renal impairment,Hepatic impairment.

The signs and symptoms that are produced after the acute overdosage of Vandetanib include Diarrhea, Hypertension, Rashes, QT prolongation.The symptomatic adverse reactions produced by Vandetanib are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Blurred vision, Rashes, Hypertension, QT prolongation.

Vandetanib is primarily indicated in conditions like Thyroid cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Tumor induced angiogenesis.

No data regarding the interactions of Vandetanib was found.

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store Below 30°C.

Vandetanib should not be started in patients with QTc prolongation and in patients with a history of torsade de points unless corrected. Monitor ECG and blood tests during treatment. Maintain a normal range of serum electrolytes to reduce the risk of QTc prolongation. It should not be used in patients with posterior reversible encephalopathy syndrome. This syndrome should be considered in patients with seizures, headache, visual disturbances, confusion or altered mental function. Discontinue the drug if Steven Johnsons syndrome or severe diarrhea occur. Wear protective clothing and use sunscreen to prevent phototoxicity. Use with caution in patients with brain metastases, heart failure, hypertension, renal and hepatic impairment, ALT elevation or interstitial disease.