Azilisartan Medoxomil

Azilisartan Medoxomil is a prodrug and selective AT1 subtype Angiotensin II Receptor Antagonist.It is hydrolyzed to Azilisartan in GI tract. It blocks the binding of Angiotensin II to the AT1 receptor in vascular smooth muscle and adrenal gland and inhibits effect of Angiotensin.It is given for the treatment of hypertension


Brands
Adult Dose
Dose: 40 to 80 mg
Single Dose: 60 (60)
Frequency: 24 hourly
Route: oral
Instructions: can be taken with or without food
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Benziimidazole Carboxylate. It belongs to Angiotensin-II receptor antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Azilisartan Medoxomil is 606.62.
Contraindications
Azilisartan Medoxomil is contraindicated in conditions like Pregnancy,Lactation.
Effects
The symptomatic adverse reactions produced by Azilisartan Medoxomil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Fatigue, Nausea, Diarrhea, Cough, Asthenia, GI disorders, muscle spasm.
Indications
Azilisartan Medoxomil is primarily indicated in conditions like Hypertension.
Interactions
No data regarding the interactions of Azilisartan Medoxomil was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 20°C-25°C. Protect from Sunlight and Moisture.
Warnings
Discontinue drug in nursing. Avoid fetal and neonatal exposure.Monitor for worsening renal function in patients with renal artery stenosis.Correct volume salt depletion prior to its administration.Drink plenty of fluid while taking Azilisartan. Salt diet with Azilisartan can lead to dizziness and hypotension.Similarly the patients with diarrhea and vomitting are also at risk of developing dizziness and hypotension
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