Dose: 10 to 40 mg
Single Dose: 25 (25)
Frequency: 24 hourly
Route: PO
Instructions: initial 10mg OD for 7days , followed by 20mg OD for 7days, then increase to 40mg OD._x000D_Vilazodone should be taken with food

. It is of Synthetic origin and belongs to Piperazinyl HCl. It belongs to Seletive Serotonin Reuptake Inhibitor pharmacological group on the basis of mechanism of action.

Vilazodone

The signs and symptoms that are produced after the acute overdosage of Vilazodone include Disorientation, Hallucinations, Lethargy, Restlessness, serotonin syndrome.The symptomatic adverse reactions produced by Vilazodone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Fatigue, Diarrhea, Palpitation, Insomnia, Dry mouth, Dyspepsia, Erectile dysfunction, Somnolence, Tremor, Arthralgia, Nausea and vomiting, Paresthesias, Gastroenteritis, Delayed ejaculation, Abnormal dreams, decrease libido, orgasm abnormal.

Vilazodone is primarily indicated in conditions like Major Depressive Disorder.

Vilazodone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinNSaids, increase risk of bleedingcareful monitoring should be institutedErythromycinErythromycin is moderate CYP3A4 inhibitor , it can increase vilazodone plasma concentration vilazodone dose should be reduced to 20mg for patients with intolerable adverse events.Ketoconazoleketonconazole a strong CYP3A4 inhibitor , it can increase vilazodone plasma concentration by 50%.vilazodone dose should be reduced to 20mg if coadministered with a strong inhibitor of CYP3A4RifampicinCyp3A4 inducer e.g Rifampicin may decrease vilazodone exposureSertraline (HCl)sertraline is MAOIs ( mono amino oxidase inhibitor) and fatal risks are associated with itMAOIs are Contraindicated with VilazodoneVORICONAZOLECYP3A4 Inhibitors (Strong) may increase the serum concentration of Vilazodone.Vortioxetineincreases toxicity of vortioxetineuse alternativeWarfarin (Na)Drug interefreing with hemostasis such as anticoagulant e.g warfarin may increase risk of bleedingcareful monitoring should be instituted These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, and Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

tab Store Between 15°C-30°C.

Scuidal ideation, worsening of Depression, scuidality in Adults, pediatrics Observe , monitor Closely for clinical Worsening, scuidality, behavioural changes. Screen Patients for bipolar Disorders, because it is not recommended in bipolar disorders. Monitor for emergence of Serotonin syndrome or NMS like sign and symptoms take cautions with mania , hypomania, monitor symptoms of withdrawal discontinue treatment in patient with hyponatremia and intervention should be instituted