Tocilizumab

Toclizumab is recombinant humanized Anti human Interleukin 6 (IL-6) Receptor monocolonal antibody of the immunoglobulin IgG1k( Gamma 1,Kappa) with a typical polypeptide structure. Toclizumab binds specifically to both soluble and membrane bound IL-6 receptors , and inhibit IL-6 mediated signalling through these receptors, thereby reducing the inflammootry processes in patients with rhematoid arthritis and systemic juvenile rhematoid idiopathic arthritis

Brands
Adult Dose
Dose: 4 to 8 mg/kg
Single Dose: 6 (6)
Frequency: As recommended.
Route: IV infusion
Instructions: it is administered every 4 week
Neonatal
Paedriatic
Dose: 8 to 12 mg/kg
Single Dose: 10 (10)
Frequency: As recommended.
Route: iv infusion
Instructions: it is administered every 2 week
Characteristics
. The Molecular Weight of Tocilizumab is 148.00. It is weakly acidic drug.
Contraindications
Tocilizumab is contraindicated in conditions like Hepatic impairment,Hypersensitivity to the drug.
Effects
Tocilizumab produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Tocilizumab therapy.The symptomatic adverse reactions produced by Tocilizumab are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Hypertension, Respiratory tract infections, Nasopharyngitis.
Indications
Tocilizumab is primarily indicated in conditions like Juvenile rheumatoid arthritis, Rheumatoid arthritis.
Interactions
No data regarding the interactions of Tocilizumab was found.
Interfrence
Decreases ESRIncrease Haemoglobin
Risks
Drug should not be given to Pregnant Mothers, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
injection
Warnings
The drug can cause serious infections, GI perforations and Hypersensitivity reactions.The ddrug should not be given with live vaccines
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