Dalfampridine

Dalfampridine (4-amino pyridine) is used to improve walking in patients with multiple sclerosis. It acts by blocking potassium channels due to which conduction in focally demyelinated axons is increased because of which it enhances muscle contraction and thereby improves walking in patients

Brands
Adult Dose
Dose: 10 to 10 mg
Single Dose: 10 (10)
Frequency: 12 hourly
Route: oral
Instructions: Do not take more than two tablets in a 24 hr period.Take tablets whole .Do not crush , chew or dissolve tablets. The drug can be taken with or wothout food. Do not take the drug with other aminopyridine medications
Neonatal
Paedriatic
Characteristics
belongs to 4-Amino Pyridine. It belongs to Potassium Channel (ATP sensitive) antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Dalfampridine is 94.12. Its pKa is 9.17.
Contraindications
Dalfampridine is contraindicated in conditions like Seizures,Renal impairment.
Effects
The severe or irreversible adverse effects of Dalfampridine, which give rise to further complications include Seizures, Dizziness, Urinary tract infection.Dalfampridine produces potentially life-threatening effects which include Seizures, multiple sclerosis relapse. which are responsible for the discontinuation of Dalfampridine therapy.The signs and symptoms that are produced after the acute overdosage of Dalfampridine include Confusion, hypophonic speech, Temporal lobe hyperintensities, Weakness, reduced awareness, altered mental state, complex partial seizures, memory loss.The symptomatic adverse reactions produced by Dalfampridine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Ataxia, Nausea, Constipation, Insomnia, Confusion, Dyspepsia, Asthenia, Visual disturbances, Back pain, Nasopharyngitis, balance disorder, pharyngolaryngeal pain, parasthesia.
Indications
Dalfampridine is primarily indicated in conditions like Multiple sclerosis.
Interactions
No data regarding the interactions of Dalfampridine was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 15°C-30°C. Protect from Moisture.
Warnings
do not administer dalfampridine in patients with seizures, ,renally impaired patients ,concurrent treatment with other forms of 4-Amino pyridine and in urinary tract infections
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