Carglumic Acid

Carglumic Acid or N-carbamoyl L-Glutamic Acid is an aminoacid and is an structural analogue of N-Acetylglutamate that acts by activating carbamoyl Phosphate synthetase enzyme which catalyzes the formation of Arginine and Urea from ammonia and thereby lowers blood ammonia level.Carglumic acid is indicated for the treatment of hyperammonemia and hyperglutamenemia due to N-Acetylglutamate synthetase (NAGS) deficiency

Brands
Adult Dose
Dose: 100 to 250 mg/kg/day
Single Dose: 180 (175)
Frequency: 12 hourly
Route: oral
Instructions: Each 200 mg should be dispersed in 2.5 ml of water and taken immediately. It shoild be taken before meal. It should not be swallowed whole or crushed
Neonatal
Paedriatic
Characteristics
belongs to N-Acetyl Glutamate. . The Molecular Weight of Carglumic Acid is 190.00.
Contraindications
Carglumic Acid
Effects
Carglumic Acid produces potentially life-threatening effects which include Anemia, Infection. which are responsible for the discontinuation of Carglumic Acid therapy.The signs and symptoms that are produced after the acute overdosage of Carglumic Acid include Tachycardia, Sweating, Restlessness, Increased bronchial secretion.The symptomatic adverse reactions produced by Carglumic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Vomiting, Diarrhea, Abdominal pain, Pyrexia, Ear disorders, Nasopharyngitis, Tonsilitis.
Indications
Carglumic Acid is primarily indicated in conditions like Hyperammonemia.
Interactions
No data regarding the interactions of Carglumic Acid was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Protect from Moisture.
Warnings
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