Ceftaroline fosamil

Ceftaroline fosamil is broad-spectrum, prodrug antibacterial of cephalosporin class of beta-lactams (β-lactams). Chemically, the prodrug, ceftaroline fosamil monoacetate monohydrate is (6R,7R)-7-{(2Z)-2-(ethoxyimino)-2-[5- (phosphonoamino)-1,2,4 thiadiazol-3-yl]acetamido}-3-{[4-(1- methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl}8-oxo-5- thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate monoacetate monohydrate. The empirical formula is C22H21N8O8PS4€¢C2H4O2€¢H2O.


Brands
Adult Dose
Dose: 200 to 200 mg
Single Dose: 200 (200)
Frequency: 12 hourly
Route: IV infusion
Instructions: (For patient with end-stage renal disease (ESRD), including hemodialysis) IV infusion administered over 1 hour. Constitution time is less than 2 minutes. Mix gently and check that the content has dissolved.
Neonatal
Paedriatic
Characteristics
. It is of Semi Synthetic origin and belongs to Cepahalosporin. It belongs to Antibiotic (Cell Wall) pharmacological group on the basis of mechanism of action. The Molecular Weight of Ceftaroline fosamil is 762.75.
Contraindications
Ceftaroline fosamil is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Ceftaroline fosamil, which give rise to further complications include Hepatitis, Renal failure, Hypersensitivity.The symptomatic adverse reactions produced by Ceftaroline fosamil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Vomiting, Diarrhea, Palpitation, Tachycardia, Constipation, Abdominal pain, Rashes, Urticaria, Thrombocytopenia, Neutropenia, Pyrexia, Anemia, Convulsions, Hepatitis, Hyperglycemia, Anaphylaxis, esinophilia, hyperkalemia.
Indications
Ceftaroline fosamil is primarily indicated in conditions like Bacterial skin infections, Community acquired pneumonia.
Interactions
No data regarding the interactions of Ceftaroline fosamil was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Injection Use within seven days if kept at room temperature.
Warnings
Exercise caution in patients with known hypersensitivity to beta-lactam antibiotics. Clostridium difficile-associated diarrhea (CDAD) has been reported with nearly all systemic antibacterial agents, including Ceftaroline fosamil. Evaluate if diarrhea occurs. If anemia develops during or after therapy, a diagnostic workup for drug-induced hemolytic anemia should be performed and consideration given to its discontinuation . Use with caution in nursing mother.
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