Olopatadine

Olopatadine is a potent selective antiallergic/antihistaminic agent. It has multiple distinct mechanisms of action. It antagonises histamine (the primary mediator of allergic response in humans) and prevents histamine induced inflammatory cytokine production by human conjunctival epithelial cells. Data from in vitro studies suggest that it may act on human conjunctival mast cells to inhibit the release of pro-inflammatory mediators. In patients with patent nasolacrimal ducts, topical ocular administration of olopatadine was suggested to reduce the nasal signs and symptoms that frequently accompany seasonal allergic conjunctivitis. It does not produce a clinically significant change in pupil diameter.

Brands
WINOLAP WINOLAP APTADINE OGATE OLOTEK OLOTEK OLOMINE XEPAT PATADIN PATADIN-2 XEPAT FORT ZOLOPAT FORTE OLOPAT OLOPAT OLUP OLOPINE OLOPINE
Adult Dose
Dose: 2.22 to 0 mg/ml
Single Dose: 1.1 (1.11)
Frequency: 24 hourly
Route: opthalmic
Instructions: The dose is one drop of olopatadine in the conjunctival sac of the affected eye(s) twice daily (8 hourly). Treatment may be maintained for up to four months, if considered necessary.
Neonatal
Dose: 2.22 to 0 mg/ml
Single Dose: 1.1 (1.11)
Frequency: 24 hourly
Route: opthalmic
Instructions: The dose is one drop of olopatadine in the conjunctival sac of the affected eye(s) twice daily (8 hourly). Treatment may be maintained for up to four months, if considered necessary.
Paedriatic
Dose: 2.22 to 0 mg/ml
Single Dose: 1.1 (1.11)
Frequency: 24 hourly
Route: opthalmic
Instructions: The dose is one drop of olopatadine in the conjunctival sac of the affected eye(s) twice daily (8 ho
Characteristics
Olopatadine hydrchloride is the derivative of Olopatadine. It is of Synthetic origin. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Olopatadine is 373.90. Its pKa is 9.4 (piperidinium cation), 5.6 (pyridinium cation).
Contraindications
Olopatadine is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The symptomatic adverse reactions produced by Olopatadine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Tiredness, Headache, Nausea, Blurred vision, Cough, Asthenia, Dermatitis, Rhinitis, Eye irritation, Photophobia, Dryness of eye, Burning eyes, Eye Pain, Sinusitis, Flu like syndrome, Dryness of nose, Hyperemia, Foreign body sensation, Increased tearing, Lids edema, Infection, Back pain, dizziness, stingling, stingling, Weakness.
Indications
Olopatadine is primarily indicated in conditions like Allergic conjunctivitis.
Interactions
No data regarding the interactions of Olopatadine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Eye drop Store Between 15°C-30°C. Do not Freeze.
Warnings
Do not instill olopatadine hydrochloride ophthalmic solution while wearing contact lenses, but to wait for 10 minutes after instillation before inserting contact lenses. Do not touch the eyelids or surrounding areas with the dropper tip of the bottle. It is only for topical use. Olopatadine should be used with caution during lactation. It should not be used to treat contact lens related irritation.
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