Dexfenfluramine (HCl)

Dexfenfluramine (HCl) is a selective 5-HT agonist. effective in reducing obesity.


Brands
Adult Dose
Dose: 0.214 mg/kg
Single Dose: 0.21 (0.214)
Frequency: 12 hourly
Route: PO
Instructions: For Max 3 Months
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Fenfluramine. It belongs to Anorectic Agent pharmacological group on the basis of mechanism of action and also classified in Obesity pharmacological group.The Molecular Weight of Dexfenfluramine (HCl) is 267.70. Its pKa is 9.1.
Contraindications
Dexfenfluramine (HCl) is contraindicated in conditions like Glucoma.
Effects
Dexfenfluramine (HCl) produces potentially life-threatening effects which include Valvulary heart defects, Pulmonary hypertension. which are responsible for the discontinuation of Dexfenfluramine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Dexfenfluramine (HCl) include Tachycardia, Convulsions, Restlessness, Ventricular arrhythmias, Excitement.The symptomatic adverse reactions produced by Dexfenfluramine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Fatigue, Nausea, Vomiting, Constipation, Dry mouth, Polyuria, Xerostomia, Dry mouth, dizziness.
Indications
Dexfenfluramine (HCl) is primarily indicated in conditions like Eating behavior disorders, Obesity.
Interactions
No data regarding the interactions of Dexfenfluramine (HCl) was found.
Interfrence
False +ve urine drug test
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store at room temperature.
Warnings
Dexfenfluramine should be avoided in patients with pulmonary hypertension, past or current history of cardiovascular or cerebrovascular disease, psychiatric disease, glaucoma, epilepsy, history of drug abuse. It should be used with extreme caution in elderly or during pregnancy or lactation. Avoid abrupt withdrawl. Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness, extreme fatigue and depression. It should be used with caution and monitor blood pressure in patients with mild hypertension. Dose titration and dose discontinuance may be necessary in epileptic patients.
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