Rifaximin

Rifaximin is nonsystemic antibiotic derived from rifamycin SV. Rifaximin is a structural analog of rifampin. The empirical formula is C43H51N3O11. This non-systemic property of the drug is due to the addition of a pyridoimidazole ring, which renders it non-absorbable. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme and also contributes to restore intestinal microflora imbalance. Other studies have also shown rifaximin to be an pregnane X receptor (PXR) activator. As PXR is responsible for inhibiting the proinflammatory transcription factor NF-kappa B and is inhibited in inflammatory bowel disease (IBD), rifaximin may prove to be effective for the treatment of IBD.

Brands
XIFAXA RIFAXA NIMIXA NIMIXA Nixaf HIDROFAX
Adult Dose
Dose: 200 mg
Single Dose: 200 (200)
Frequency: 8 hourly
Route: oral
Instructions: It can be taken with or without food.
Neonatal
Paedriatic
Characteristics
Rifaximin also known as Rifaximinum. . It is of Semi Synthetic origin. It belongs to Antibiotics pharmacological group.The Molecular Weight of Rifaximin is 785.88. Its pKa is 7.67.
Contraindications
Rifaximin is contraindicated in conditions like Hypersensitivity to the drug.
Effects
Rifaximin produces potentially life-threatening effects which include Hypersensitivity reactions, Blood in stools, Shortness of breath. which are responsible for the discontinuation of Rifaximin therapy.The symptomatic adverse reactions produced by Rifaximin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Fatigue, Nausea, Vomiting, Fever, Constipation, Abdominal pain, Edema.
Indications
Rifaximin is primarily indicated in conditions like Diarrhoea caused by e-coli, Travelers diarrhoea, and can also be given in adjunctive therapy as an alternative drug of choice in Hepatic encephalopathy.
Interactions
No data regarding the interactions of Rifaximin was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 15°C-25°C.
Warnings
Discontinue rifaximin if diarrhea symptoms get worse or persist more than 24-48 hours and alternative antibiotic therapy should be considered. Do not use in diarrhea complicated by fever and/or blood in the stool or diarrhea due to pathogens other than Escherichia coli.
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