Piperaquine Phosphate

Pipreraquine is 1,3-bis-[4-(7-chloroquinolyl-4)-piperazinyl-1]- propane, is an antimalarial compound belonging to the 4-aminoquinolines. It is a highly liphophilic. Piperaquine Phosphate (PQP) interferes with physiological function of the food vacuole membrane of the trophozoites leading to autophagocytosis of the parasites. It has no marked effect on the ring forms, immature or mature schizonts and the male of female gametocytes.

Brands
ARTEQUINE ARTEQUINE DIPIP DIPIP DIPHOS ANTIMAL-RAPID ANTIMAL-RAPID NEO FANSIDAR NEO FANSIDAR TIMEQUIN TIMEQUIN ARTEPIP ARMIQIN ARMIQIN DIMISINEX
Adult Dose
Dose: 16 to 26 mg/Kg
Single Dose: 21 (21)
Frequency: 24 hourly
Route: PO
Instructions: It is available in combination with dihydroartemisinin. It should be taken with water without food. Doses are given as mg/Kg/day for three days. Maximun 4 tablets each containing 320mg Pipraquine are indicated for upto 100 Kg weight patient. However, there are no data on which to base a dose recommendation in patients weighing >100kg.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Bisquinoline. . The Molecular Weight of Piperaquine Phosphate is 999.56. Its pKa is four i.e. 6.9, 6.2, 5.7 and 5.4..
Contraindications
Piperaquine Phosphate is contraindicated in conditions like Pregnancy.
Effects
The symptomatic adverse reactions produced by Piperaquine Phosphate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Anorexia, Myalgia, Cough, Asthenia, Arthralgia, Abdominal distress, Pyrexia, Eosinophilia, QT prolongation.
Indications
Piperaquine Phosphate is primarily indicated in conditions like Malaria caused by plasmodium falciparum.
Interactions
No data regarding the interactions of Piperaquine Phosphate was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
tablet Store at room temperature, . Protect from Heat.
Warnings
It is not recommended in first trimester of pregnancy or in childem below 5 Kg.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.