Prasugrel HCl

Prasugrel is an anti-platelet agent. The chemical name is 5-[(1RS)-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride corresponding to the molecular formula C20H20FNO3S€¢HCl. Prasugrel is a prodrug, oxidation by intestinal and hepatic cytochrome P-450 enzymes convert prasugrel into its active metabolite. Its active form binds irreversibly to the adenosine diphosphate (ADP) P2Y12 receptor on platelets for their lifespan, thereby inhibiting their activation and decreasing subsequent platelet aggregation.


Adult Dose
Dose: 5 to 10 mg
Single Dose: 7.5 (7.5)
Frequency: 24 hourly
Route: PO
Instructions: Initiate with single loading dose of 60mg oral. Consider lowering the maintenance dose to 5 mg in patients
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Prasugrel HCl is 409.90. Its pKa is 5.1.
Contraindications
Prasugrel HCl is contraindicated in conditions like Bleeding,Transient ischaemic attacks.
Effects
Prasugrel HCl produces potentially life-threatening effects which include Thrombocytopenia, Bleeding, Hypersensitivity, blood in urine, blood in stool, Peripheral edema, Thrombotic thrombocytopenic purpura, Jaundice, Atrial fibrillation. which are responsible for the discontinuation of Prasugrel HCl therapy.The signs and symptoms that are produced after the acute overdosage of Prasugrel HCl include Vomiting, Blurred vision, hepatocellular atrophy, Shortness of breadth, Mydriasis, Decreased locomotor activity, Lacrimation.The symptomatic adverse reactions produced by Prasugrel HCl are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tiredness, Nausea, Diarrhea, Dyspnea, Hypotension, Cough, Pain in upper & lower extremities, Back pain, Mild headache, Minor chest pain, Abnormal hepatic function.
Indications
Prasugrel HCl is primarily indicated in conditions like Acute coronary syndrome (without st-segment elevation), Coronary artery disease, Myocardial infarction, Myocardial infarction (non st-segment elevation), Unstable angina.
Interactions
No data regarding the interactions of Prasugrel HCl was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
tab Store at room temperature, Between 15°C-30°C. Protect from Moisture and Heat.
Warnings
It can cause significant, sometimes fatal, bleeding. Do not use in patients with active pathological bleeding or a history of transient ischemic attack or stroke. In patients greater then or equal to 75 years of age, it is generally not recommended because of the increased risk of fatal and intracranial bleeding and uncertain benefit, except in high-risk patients (diabetes or prior MI), where its effect appears to be greater and its use may be considered. Do not start Prasugrel in patients likely to undergo urgent coronary artery bypass graft surgery (CABG). When possible, discontinue it at least 7 days prior to any surgery. Additional risk factors for bleeding include: Body weight
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