Cinitapride

Cinitapride is a new prokinetic agent. It is a substituted benzamide with 5-HT receptor antagonist and 5-HT- receptor agonist activity. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.


Adult Dose
Dose: 1 to 1 mg
Single Dose: 1 (1)
Frequency: 8 hourly
Route: PO
Instructions: Take 15 minutes before meal. The dose may be reduced, if required, depending on the patient’s age and symptoms.
Neonatal
Paedriatic
Characteristics
belongs to benzamide. It belongs to 5HT-1 agonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Cinitapride is 402.50. Its pKa is 16.32.
Contraindications
Cinitapride is contraindicated in conditions like Hypersensitivity to the drug,Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Cinitapride, which give rise to further complications include Angioedema, Gynacomastia, Angioedema.The signs and symptoms that are produced after the acute overdosage of Cinitapride include Drowsiness, Confusion, Extrapyramidal effects.The symptomatic adverse reactions produced by Cinitapride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Diarrhea, Sedation, Extra pyramidal symptoms.
Indications
Cinitapride is primarily indicated in conditions like Constipation, Delayed gastric emptying, Gastro-esophageal reflux disease, Non-ulcer dyspepsia.
Interactions
No data regarding the interactions of Cinitapride was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 15°C-25°C. Protect from Moisture.
Warnings
Used with caution especially in the elderly because it enhances the action of acetylcholine. It should not be used in patients in whom an increase in gastrointestinal motility could be harmful, e.g. in patients with gastrointestinal hemorrhage, mechanical obstruction or perforation. Used with caution in patients with a history of dyskinesia induced by neuroleptics. Drowsiness may occur with the use of cinitapride and hence caution is to be exercised while driving and using machines. Do not take with alcohol since increased sedation may occur.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.