Prednicarbate

Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness.

Brands
ZEMAGIS ZEMAGIS CABEDIN PRECARBAT
Adult Dose
Dose: 0.10%
Single Dose: 0.1 (0.1)
Frequency: 24 hourly
Route: Topical
Instructions: 0.1% may be used with caution in pediatric patients 1 year of age or older. The safety and efficacy of drug use for longer than 3 weeks in this population have not been established.
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Prednicarbate is 488.24.
Contraindications
Prednicarbate is contraindicated in conditions like Hypersensitivity.
Effects
The symptomatic adverse reactions produced by Prednicarbate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Rashes, Urticaria, Pruritus, Burning, Allergic contact dermatitis, Edema, Paresthesias, Skin atrophy.
Indications
Prednicarbate is primarily indicated in conditions like Pruritic manifestations.
Interactions
No data regarding the interactions of Prednicarbate was found.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Cream Store Between 15°C-25°C.
Warnings
As with other corticosteroids, therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary. Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
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