Doxofylline

Doxofylline (7-(1,3-dioxalan-2-ylmethyl) theophylline) is a novel xanthine bronchodilator which vary from theophylline in that it contains a dioxalane group in position 7. Similarly to theophylline, its mechanism of action is associated to the inhibition of phosphodiesterase behavior. Doxofylline is shown to have similar efficacy with notably less adverse effects in both animal studies as well as human adults. However, there is a lack of studies in children with asthma. Retrospective data imply that 11% patients experienced some adverse effects, but only 5% reported moderate adverse effects.

Brands
THEOZAM SYNSMA BRONAXE BRONAXE UNIFYLINE UNIFYLINE OFYLIN PROFYLLINE PROFYLLINE AGOLIX AGOLIX DOXFREE
Adult Dose
Neonatal
Paedriatic
Characteristics
Doxofylline also known as Doxofyllinum, Doxofyllinum. . It is of Synthetic origin and belongs to (7-(1,3-dioxalan-2-ylmethyl) theophylline). It belongs to Phosphodiesterase inhibitor pharmacological group on the basis of mechanism of action and also classified in Bronchodilator pharmacological group.The Molecular Weight of Doxofylline is 266.30. It is weakly alkaline drug.
Contraindications
Doxofylline is contraindicated in conditions like Hypersensitivity to xanthine derivatives,Acute myocardial infarction.
Effects
The severe or irreversible adverse effects of Doxofylline, which give rise to further complications include Seizures, Arrythmia, low blood sugar.The signs and symptoms that are produced after the acute overdosage of Doxofylline include Paroxysmal spasm crises, Arrhythmias.The symptomatic adverse reactions produced by Doxofylline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Irritability, Nausea, Vomiting, Tachycardia, Insomnia, Abdominal pain, Heart burn, Shortening of breath, Contractions, Proteinuria, Hyperglycemia.
Indications
Doxofylline is primarily indicated in conditions like Bronchial asthma, Bronchospasm, Chronic asthmatic bronchitis.
Interactions
No data regarding the interactions of Doxofylline was found.
Interfrence
Gastric & Liver ulserSerious short of O2 supply pateint
Risks
Drug should not be given to Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Doxofylline not xanthine with other drugs taken at the same time, proposed not to drink beverages and foods containing caffeine. Adrenaline and ephedrine or other drugs necessary to be careful with clothes. To alleviate symptoms of adverse effects, may suspend medication, if necessary, medical diagnosis, but in the signs of poisoning and the symptoms disappeared completely after taking will continue. It should be given with cuation to pateints with peptic uluration hyperthycoidism, cardiac arrythmias.
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