Telbivudine

The FDA approved telbivudine in September 2000. it is used for the treatment of chronic hepatitis B in adults. In patients with active disease, it prevents the hepatitis virus from replicating. The hepatitis B virus uses an enzyme called reverse transcriptase to make DNA and replicate. Telbivudine is an antiretroviral drug. It binds to reverse transcriptase and is incorporated into the DNA strand that the enzyme is making. This process stops the enzyme from extending the length of the DNA strand, and thereby prevents the viruses from replicating

Brands
SEBIVO TELBIVUDINE VIZEKA
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. It belongs to Antiviral Agents pharmacological group on the basis of mechanism of action and also classified in Antiretroviral Agent-Nucleoside pharmacological group.
Contraindications
Telbivudine is contraindicated in conditions like Myopathy.
Effects
The symptomatic adverse reactions produced by Telbivudine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Abdominal pain, Malaise, Cough, Elevation of CPK, Respiratory tract infections, Nasopharyngitis.
Indications
Telbivudine is primarily indicated in conditions like Hepatitis B.
Interactions
No data regarding the interactions of Telbivudine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Severe worsening of hepatitis B symptoms have been reported in patients who discontinued anti-hepatitis B therapy. Some cases of muscle injury (aches, weakness, and biochemical markers of cell damage) have been reported with telbivudine use several weeks to months after starting therapy. Telbivudine is eliminated primarily by the kidneys. Therefore, doses are often adjusted in people with kidney impairment. Telbivudine does not prevent the transmission of the virus from one person to another.
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