Ranibizumab

Ranibizumab belongs to growth factors vascular endothelial A (VEGF-A) antagonists. It works by blocking the abnormal growth of blood vessels and leakage into the eye(s) that can loss vision in people with wet AMD i.e. age-related macular degeneration.


Brands
Adult Dose
Dose: 0.5 mg
Single Dose: 0.5 (0.5)
Frequency: As recommended.
Route: intravitreal
Instructions: once a month (approximately 28 days). Although less effective, treatment may be reduced to one injection every three months after the first four injections if monthly injections are not feasible. Compared to continued monthly dosing, dosing every 3 months will lead to an approximate 5-letter (1-line) loss of visual acuity benefit, on average, over the following 9 months. Patients should be evaluated regularly. Adequate anesthesia and a broad-spectrum microbicide should be given prior to the intravitreal injection.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Ranibizumab is 48.00. It is weakly acidic drug.
Contraindications
Ranibizumab is contraindicated in conditions like Hypersensitivity,Ocular inflammation.
Effects
The symptomatic adverse reactions produced by Ranibizumab are more or less tolerable and if they become severe, they can be treated symptomatically, these include Lacrimation, Eye irritation, Blepharitis, Eye Pain, Conjunctival hyperemia, Cataract, Dry eye, Visual disturbances, Intraocular inflammation, Intraocular pressure, Vitreous floaters, Vitreous detachment, Foreign body sensation in eyes, Eye Pruritis, Ocular hyperemia, Retinal disorder, Maculopathy.
Indications
Ranibizumab is primarily indicated in conditions like age-related macular degeneration..
Interactions
No data regarding the interactions of Ranibizumab was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Do not Freeze. Protect from Sunlight. Use within mentioned date, if refrigerated.
Warnings
Pregnancy Category C. It is also not known whether ranibizumab can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. It should be given to a pregnant woman only if clearly needed. aution should be exercised when Ranibizumab is administered to a nursing woman. No notable difference in treatment effect was seen with increasing age in any of the studies.
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