Desipramine (HCl)

Desipramine (HCl) is a tricyclic antidepressant. Desipramine (HCl) is the monodemethyl derivative of imipramine and Desipramine (HCl) is less sedating than its parent compound. Two to three weeks are required to obtain the full effects of the drug. It may also be used to treat nerve pain, insomnia and bed-wetting in children.

Brands
Adult Dose
Dose: 0.357 to 0.952 mg/kg
Single Dose: 0.65 (0.6545)
Frequency: 8 hourly
Route: PO
Instructions: -
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Imipramine. It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group.The Molecular Weight of Desipramine (HCl) is 302.80. Its pKa is 10.2.
Contraindications
Desipramine (HCl) is contraindicated in conditions like Cardiac arrhythmia,Mania,Myocardial infarction,Heart block,Hepatic disease,Narrow-angle glaucoma,Urinary retention.
Effects
The severe or irreversible adverse effects of Desipramine (HCl), which give rise to further complications include Hepatitis, Agranulocytosis.The signs and symptoms that are produced after the acute overdosage of Desipramine (HCl) include Hypotension, Coma, Epileptic seizures, Respiratory depression, Tremor, Ventricular arrhythmias, Delayed cardiac conduction.The symptomatic adverse reactions produced by Desipramine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Anxiety, Palpitation, Abdominal pain, Sleep disturbancesX, Dry mouth, Blurred vision, Confusion, Pruritus, Sedation, Photosensitivity, Weight gain, Tremor, Postural hypotension, Mydriasis, Allergic skin reactions, Vasculitis, Xerostomia, Erectile impotence, Urinary RetentionX, Urinary retention, Dry mouth, Confusion, dizziness.
Indications
Desipramine (HCl) is primarily indicated in conditions like Cocaine addiction, Depression prophylaxis, Depression treatment, Enuresis.
Interactions
Desipramine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBethanidine (Sulphate)ChloroquineClonidine (HCl)Clonidine (HCl)Debrisoquine (Sulphate)GuanethidineIndacaterolprolong QTc intervalmonitor closelyLithiumLoprazolamTheoretical potential for LOPRAZOLAM increasing the SEDATIVE effect of DESIPRAMINE HYDROCHLORIDE. ModerateMay need to avoid combinationMethyldopaMethylphenidate (HCl)Mibefradil (Di HCl)NabiloneConcurrent use may increase the efficacy of nabilone.Concurrent use should be avoided, or you may need dosage adjustments or special tests during treatment.Propafenone (HCl)Riboflavin (Vitamin B2)Tricyclic antidepressants may reduce levels of riboflavin in the body. In addition to raising levels of the vitamin in the body, taking riboflavin may also improve the effects of these antidepressantsRitonavirVORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation Vortioxetineincreases the level of vortioxetinemonitor closely, use alternative These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Desipramine should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity, because it may produce allergic reaction (including bronchial asthma). Monitor ECG before initiating large doses of tetracyclines. Avoid concurrent administration with electric shock therapy because may increase the hazards of therapy. Perform periodic leukocytes (white blood cells) counts and liver function tests. Photosensitization may occur so caution patients to take protective measures, sunscreens etc, against exposure to UV light or sun light.
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