Artesunate

Artesunate is an antimalarial agent. It is a water-soluble hemisuccinate derivative of dihydroartemisinin. Artesunate and its active metabolite dihydroartemisinin are potent blood schizonticides, active against the ring stage of the parasite. Artesunate is ideal for the treatment of severe malaria, including cerebral malaria. It is also active against chloroquine and mefloquine resistant strains of P. falciparum. It is unstable in neutral solution and is therefore only available for injections as artesunic acid. The injectable formulation must be prepared immediately before use in 5% (w/v) sodium bicarbonate solution to produce the salt sodium artesunate.

Brands
ARTESUL ARTESUL FANSI PLUS SP-MAL ARAQAL ARAQAL ARAQAL ARAQAL ARAQAL ARAQAL ARAQAL ARAQAL ARAQAL MEDISONATE MISONATE ARTEDOXIN ARTEDOXIN P GEN ART SP GENART-SP METHER SP SINDA-MP SINDA-MP ARTIQUIN ARTIWEL
Adult Dose
Dose: 2.4 mg/kg
Single Dose: 2.4 (2.4)
Frequency: As recommended.
Route: IM
Instructions: Severe malaria: This dose is followed by 1.2mg/Kg at 12 and 24 hours then 1.2mg/Kg daily for 6 days. If the patient can swallow, the daily dose can be given orally.
Neonatal
Paedriatic
Characteristics
. It is of Semi Synthetic origin. . The Molecular Weight of Artesunate is 384.42.
Contraindications
Artesunate is contraindicated in conditions like Hypersensitivity,Pregnancy.
Effects
The signs and symptoms that are produced after the acute overdosage of Artesunate include Cardiotoxicity.The symptomatic adverse reactions produced by Artesunate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Vomiting, Diarrhea, Fever, Abdominal pain, Rashes, Itching, Hair loss, Convulsions.
Indications
Artesunate is primarily indicated in conditions like Cerebral malaria, Chloroquine resistant malaria.
Interactions
No data regarding the interactions of Artesunate was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Use cautiously in pregnancy and lactation,renal or hepatic dysfunction.Other drugs should be taken only with concurrence of the doctor. Artesunate should not to be used as a first line treatment of malaria. Parenteral artesunate should be used for the treatment of severe falciparum malaria only where there is evidence that the antimalarial efficacy of quinine is declining.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.