Gemifloxacin

Gemifloxacin belongs to Flouroquinolone, which are used for management of various bacterial infections. It kills a variety of bacteria, and prevent their reproduction and is often used for the treatment of infections all over the body. However, they are not considerably good for the management of viral infections like flu. Gemifloxacin inhibits the synthesis of DNA by inhibiting DNA gyrase and topoisomerase IV is the enzyme which is needed for bacterial growth.


Adult Dose
Dose: 320 mg daily
Single Dose: 320 (320)
Frequency: As recommended.
Route: PO
Instructions: Doses should be reduced if patient has kidney problem.
Neonatal
Paedriatic
Characteristics
Gemifloxacin mesilate, Gemifloxacin mesilate are the derivatives of Gemifloxacin. It is of Synthetic origin and belongs to Flouroquinolones. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Aminoquinolines pharmacological group.The Molecular Weight of Gemifloxacin is 485.50.
Contraindications
Gemifloxacin is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Gemifloxacin, which give rise to further complications include Jaundice, Jaundice, Seizures, Bleeding, Diarrhea, Tremors.Gemifloxacin produces potentially life-threatening effects which include QT prolongation. which are responsible for the discontinuation of Gemifloxacin therapy.The signs and symptoms that are produced after the acute overdosage of Gemifloxacin include Convulsions, Kidney failure, Confusion, Stomach upset, Headache, Delusions.The symptomatic adverse reactions produced by Gemifloxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Irritability, Diarrhea, Restlessness, Abdominal pain, Rashes, Nausea and vomiting, dizziness.
Indications
Gemifloxacin is primarily indicated in conditions like Bacterial infections, Chronic bronchitis, Cold, Lower respiratory tract infections, Pneumonia, Upper respiratory tract infections, and can also be given in adjunctive therapy as an alternative drug of choice in Diarrhoea.
Interactions
Gemifloxacin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementRutin (Vitamin P)Rutin may competitively inhibit action of Gemifloxacin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Aspartate Aminotransferase Assay Bilirubin (increased level)Increased level of alanine aminotransferaseGGT Increased
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
tabs Store in a well closed container, . Protect from Sunlight, Moisture and Heat.
Warnings
Should be use with caution in patients with epilepsy or history of seizures, pregnant or breastfeeding patients.Gemifloxacin should be stopped at the first sign of a skin rash or any other allergic reaction nad seek for medical doctor. Though rare, serious and seldom fatal allergic reactions have been reported, even after the first dose.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.