Pregabalin

Pregabalin, is the first drug approved by FDA for the treatment of fibromyalgia. Lyrica is also used for the relieve of nerve pain or seizures. Pregabalin is chemically similar to the drug Neurontin (gabapentin).


Adult Dose
Dose: 150 to 300 mg/day
Single Dose: 220 (225)
Frequency: 1 hourly
Route: Oral
Instructions: This dose is for neuropathic pain associated with diabetic peripheral neuropathy and for epilepsy .Reduce the dose to 75 mg when creatinine clearance is 30-60 ml/ min and up to 25-50 mg when creatinine clearance is 15-30 ml/min or below that
Neonatal
Paedriatic
Characteristics
Pregabalin also known as gabapentin. . It is of Synthetic origin. . The Molecular Weight of Pregabalin is 159.23. Its pKa is pKa1 4.2 and pKa2 10.6.
Contraindications
Pregabalin is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Pregabalin, which give rise to further complications include Chest pain.Pregabalin produces potentially life-threatening effects which include Suicidal action, Chest pain, jerking. which are responsible for the discontinuation of Pregabalin therapy.The symptomatic adverse reactions produced by Pregabalin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Vomiting, Constipation, Dry mouth, Blurred vision, Weight gain, Somnolence, Diplopia, Edema, Increased appetite, Abnormal thinking.
Indications
Pregabalin is primarily indicated in conditions like Adjunctive treatment of partial seizures, Epilepsy, Fibromyalgia, Neuropathic pain.
Interactions
No data regarding the interactions of Pregabalin was found.
Interfrence
Elevaions in creatinine phosphokinase levels
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store . Capsules Store in a well closed container, Between 15°C-30°C. Protect from Moisture and Heat.
Warnings
Do not drink alcohol while taking pregabalin. Alcohol can add to the drowsiness caused by this medication. Doctor should be informed if the patient is allergic to pregabalin. Tell your doctor and pharmacist if you are taking or planning to take other prescription and nonprescription medications, nutritional supplements, vitamins,and herbal products.Caution should be exercised when prescribing pregabalin to patients who have had a previous episode of angioedema. Patients who have had a previous episode of angioedema should be prescribed pregabalin with caution.
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