Thymosin alpha one

'Thymosin alpha-1 (TA1) is an investigational drug in Phase II trials for the treatment of chronic hepatitis B and in Phase III trials for the treatment of chronic hepatitis C. Phase II trials for hepatocellular carcinoma, malignant melanoma, and drug-resistant tuberculosis were scheduled to begin in fall 2000 (R. Koh, SciClone Pharmaceuticals, personal communication, 2000 May 5). TA1 has been granted orphan drug status for the treatment of chronic hepatitis B, HIV, hepatocellular carcinoma, and DiGeorge''s syndrome with immune defects. (Di George''s syndrome is a congenital birth defect that leads to hypoplasia or aplasia of the thymus and parathyroid glands, cardiac defects, and immune system dysfunction).'

Brands
ZADAXIN
Adult Dose
Dose: 1 mg
Single Dose: 1 (1)
Frequency: As recommended.
Route: IM,SC
Instructions: twice a week. (This dose is used in clinical trials for HIV/AIDS.)
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Polypeptide. It belongs to Immune Modifiers pharmacological group on the basis of mechanism of action and also classified in Hormones pharmacological group.It is weakly acidic drug.
Contraindications
Thymosin alpha one is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The signs and symptoms that are produced after the acute overdosage of Thymosin alpha one include Nausea, Vomiting, fatigue, Muscle aches, Fever, Neutropenia.
Indications
'Thymosin alpha one is primarily indicated in conditions like AIDS, Chronic hepatitis B infection, DiGeorge''s syndrome, Hepatitis C, Lung cancer, Malignant melanoma.'
Interactions
No data regarding the interactions of Thymosin alpha one was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in refrigerator. Do not Freeze.
Warnings
Thymosin comes as two doses in one small bottle. Once mixed with sterile water, the SECOND dose must be taken with TWO DAYS, or the drug will become too weak to be useful.TA1(Thymosin Alpha 1) is classified as being in pregnancy category C. Teratogenicity studies in both mice and rabbits have not demonstrated any difference when comparing TA1-treated and control animals. However, there are no data on TA1 in pregnant or nursing women. It is recommended that caution be exercised when administering the drug to nursing mothers.
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