Demeclocycline (HCl)

Demeclocycline is a tetracycline antibiotic. Tetracyclines are derivatives of polycyclic naphthacenecarboxamide. Tetracyclines are broad spectrum antibiotic. They are bacteriostatic and effective against many gram positive and gram negative bacterias. Demeclocycline was obtained by the demethylation of chlortetracycline. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed. Demeclocycline (HCl) is important to take the drug for the full time period as prescribed. If you discontinue the drug, it may result in ineffective treatment.

Brands
COMBIDENT PASTE
Adult Dose
Dose: 8.571 to 12.857 mg/kg
Single Dose: 11 (10.714)
Frequency: 8 hourly
Route: PO
Instructions: Upto 3 Days after Cure
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Semi Synthetic origin and belongs to Tetracycline. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Demeclocycline (HCl) is 501.30. Its pKa is 3.3, 7.2, 9.3.
Contraindications
Demeclocycline (HCl) is contraindicated in conditions like Systemic lupus erythematosus,Renal impairment,Hepatic impairment.
Effects
The severe or irreversible adverse effects of Demeclocycline (HCl), which give rise to further complications include Staining of developing teeth, Hypoplasia of enamel, Reversible neutrogenic diabetes.Demeclocycline (HCl) produces potentially life-threatening effects which include Anaphylaxis, Liver damage. which are responsible for the discontinuation of Demeclocycline (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Demeclocycline (HCl) include GI disturbances.The symptomatic adverse reactions produced by Demeclocycline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Nausea, Vomiting, Anorexia, Diarrhea, Skin reactions, Maculopapular rash, Urticaria, Vaginitis, Photosensitivity, Polyuria, Glossitis, StomatitisX, Elevation of liver enzymes, Hypersensitivity, Hemolytic anemia, Thrombocytopenia, Neutropenia, Intracranial hypertension, Dysphagia, Enterocolitis, Erythematous rash, Eosinophilia, Bulging fontanelle in Infants, Monilial overgrowth, Polydipsia, Erythematous rash.
Indications
Demeclocycline (HCl) is primarily indicated in conditions like Acne, Bacterial infections, Genitourinary tract infections, GI infections, Long-term treatment of healed gastro-oesophageal reflux disease, Pneumonia, Respiratory tract infections, Soft tissue infections.
Interactions
Demeclocycline (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementClavulanic AcidColestipol (HCl)Desmopressin (Acetate)DigoxinDemeclocycline may decrease the absorption of Digoxin.ModerateMonitor for decreased therapeutic effects of Digoxin if oral Demeclocycline is initiated/dose increased, or increased effects if oral Demeclocycline is discontinued/dose decreased. Dose spacing does not appear to help minimize this interaction. Administering I.V. formulations of digoxin will bypass this interaction.LithiumLypressinMangnese Glycerophosphatemangnese might decrease the effectiveness of tetracyclinesModerateTake manganese two hours before or four hours after taking tetracyclinesSodium BicarbonateTheophyllineThiomersalVasopressin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Demeclocycline should be used with caution (if contain tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma). Take appropriate measures if secondary infection occurs. Perform periodic laboratory evaluation of organ system (e.g. liver or kidney) in case of long term therapy.
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