PROLOX CIPROX CIPROX CIPROX CIPROX ROFLOX ROFLOX ALGOCIN ALGOCIN TENACID TENACID ADACIP ADACIP ADACIP ADACIP CILOXAN ARISTIN-C ARISTIN-C ARISTIN-C CIPOTIC CIPOTIC-D FOBIN FOBIN NEOFLOXIN NEOFLOXIN NEOFLOXIN GEN-CIPRO GEN-CIPRO GEN-CIPRO ZOLOXIN ZOLOXIN QUINOFLOX QUINOFLOX QUINOFLOX QUINOFLOX QUINOFLOX QUINOFLOX QUINOFLOX QUINOFLOX QILOX QILOX CIPLINZ CIPLINZ NICIL NICIL NICIL CIPROXIN CIPROXIN CIPROXIN CIPROXIN CIPROXIN CIPOCAINE INOQUIN INOQUIN INOQUIN CIPROMEN CIPROMEN DILOXIN DILOXIN ROXIN ROXIN SUPREME SUPREME SUPREME DV-CIPRO CIPROCAM CIPROCAM PROFLOX PROFLOX PROFLOX FLOROFLOX FLOROFLOX ORPIC ORPIC ETHIFLOX CIPRODEX CIPROCIDE CIPROCIDE CIPVAL CIPVAL CIXIN CIXIN CYFLOX NAFCIN NAFCIN NAFCIN NAFCIN NAFCIN NAFCIN NAFCIN MEDICIP MEDICIP CIALOX MEGAFLOX MEGAFLOX MEGAFLOX MEGAFLOX ORPIC ORPIC ORPIC ORPIC ORPIC ORPIC ORPIC GETCIPRO CYROCIN CYROCIN CYROCIN HIFLOX HIFLOX HIFLOX HIFLOX HIFLOX QUPRON QUPRON QUPRON QUPRON CYCIN CYCIN CYCIN CYCIN PROFACS PROFACS HIPRO HIPRO HIPRO HIPRO HIPRO EFECIP EFECIP EFECIP CIPEX CIPEX CIPLET CIPLET CIPLET CIPLET QUIC ORCID ORCID CANON CANON INVOFLOX INVOFLOX-D CIPROZAT CIPROZAT CIPROQUINE CIPROQUINE CIPROQUINE CIPZOR CIPZOR RI-Q RI-Q FLOXACIN FLOXACIN CEVOCIP CEVOCIP ROFLOXACIN ROFLOXACIN CIPROMED CIPROMED CIPROKING CIPROKING CIPROKING CIPROKING CIPROFENA LABENTROL LABENTROL LABENTROL ZINDOLIN AMESURE AMESURE AMESURE HITROXIN HITROXIN HITROXIN HITROXIN YOKOCIP YOKOCIP YOKOCIP YOKOCIP YOKOCIP AXCIN TABLET AXCIN TABLET CIPORT CIPORT QUINOCIN EXCIPRO EXCIPRO EXCIPRO CIPCIN CIP CIPOXIN CIPOXIN MERCIP MERCIP MERCIP KUINOPT KUIN KUIN KUIN EVOCIN CIPLOX CIPLOX CIPLOX CYPREX CYPREX CYPREX CYPREX GENOPOX GENOPOX SAVOXACIN SAVOXACIN CIPACIN CIPACIN PARAFLOX PARAFLOX PARAFLOX EVOFLOX EVOFLOX CIQUIN CIQUIN CIQUIN CIQUIN ARCOFLOXIN ARCOFLOXIN TUZLOX TUZLOX TUZLOX PROFACTIN PROFACTIN FLOROCIN FLOROCIN FLOROCIN REKOCIPRIN CIPROMAC CINROL CINROL QUELL QUELL SUPROX SUPROX CATEX CATEX CATEX XEOXIN XEOXIN CEMOFLOXIN CEMOFLOXIN BIONIP BIONIP NOVIDAT NOVIDAT NOVIDAT NOVIDAT NOVIDAT RIGET RIGET RIGET RIGET RIGET RIGET FEPRO FEPRO CIPROCIN CIPROCIN CINOFLOX CINOFLOX VEPROX VEPROX VEPROX VEPROX M. CIP M. CIP CICLOMIN SIROXIN SIROXIN ROZID ROZID WELKIN WELKIN NEXOGEX NEXOGEX FINCH FINCH CEPCI CEPCI GAVEL GAVEL GAVEL CIPROK CIPROK CIPROK CIPROK CIPROK CIPROK CIPROK CIPROK CIPROK CIPROK VILOC VILOC VILOC SIPROF SIPROF QUASH QUASH QUASH QUASH QUASH QUASH QUASH QUASH CPZAF CPZAF CPZAF CPZAF PROFOX FORTE PROFOX MYTIL XR MYTIL MYTIL MYTIL MYTIL MYTIL MYTIL CIPROBAY CIPROBAY CIPROBAY FOXIREX FOXIREX CIPRIN CIPRIN CIPRIN CIPRIN CIPRIN CIPRIN CIPRIN CIPRIN MEGACIP MEGACIP MEGACIP CITHROX CITHROX CITHROX CITHROX CISCAP CISCAP CISCAP CIPSA CIPSA CORSICA CORSICA FINFLOX FINFLOX EXCIP EXCIP CYNOCIP CYNOCIP CIPDEL CIPDEL ZACIN CIPRONAG CIPRONAG CIPRONAG CIPRONAG CIPROMINE E-CIP E-CIP ZEPROCAINE POLYGARD POLYGARD QUIDEX QUIDEX DEXAFLOX GYRASE GYRASE GYRASE GYRASE CIPRONET CIPRONET CLPRONET CLPRONET FLINOX FLINOX FLINOX CIKIN CIPROFINE ROCIP ROCIP ROCIP ROCIP LIGNOCIP CIPROSAFE TABLET CIPROSAFE TABLET HARFLOX HARFLOX LUCID LUCID LUCID SECOFLOXACIN SECOFLOXACIN CINOX CINOX CINOX OXIRASE OXIRASE OXIRASE OXIRASE OXIRASE OXIRASE ZECIP PROCIP PROCIP PE-KING PE-KING AMPROX AMPROX KAISEN KAISEN STARCIP STARCIP STARCIP STARCIP OCUCIPROX MEDI-LOX MEDI-LOX EMPOIR EMPOIR COFLOX LAWRCIP CIPROSAFE INFUSION CIPRODAY CIPRODAY CIPRODAY ANACIN ANACIN ANACIN ANACIN CIPREL CIPREL CIPSIF CIPSIF CIPROGEN CIPROGEN CIPROGEN CIPROGEN CIPROLEX CIPROLEX CIPROLEX GALOX GALOX OPHTHAFLOX BACIP CIPROCIL CIPROCIL CIPROCIL CIPROBACT CIPROBACT CIPROBACT CIPROBACT CIPROBACT CIPROBACT CIPROFLOXACIN CIPROFLOXACIN FLOXCIP FLOXCIP BAXIB BAXIB BAXIB METADEX EURO EURO SARIX SARIX INFU-C OPHTH-CIPRO OPHTH-CIL CIPROHEIM CIPROHEIM CIPROHEIM CIPROSCOT XR CIPROSCOT CIPROSCOT CIPROSCOT CIPROSCOT CIPROSCOT CIPFLOX CIPFLOX C OXACIN C OXACIN CIPROXSEL NOFLOX NOFLOX CIPNOLONE CIPNOLONE CIPNOLONE CIPNOLONE M-PRO M-PRO C-FLO – C-FLO ALPHACIP ALPHACIP ROZOLE ROZOLE NELSOQUIN NELSOQUIN NILSOQUIN NILSOQUIN NEXTER G.T.CIP XL G.T.CIP XL XEOXCIN XEOXCIN G.T.CIP EVERCIP EVERCIP AXCIN SUSPENSION AXCIN SUSPENSION GT CIP QUIXOR QUIXOR QUIXOR QUIXOR MARTACIN MARTACIN CIP-ERA CIP-ERA CIP-ERA CIP-ERA BACTERONIL BACTERONIL CIPROLON SIPOMED BLOSSOM BLOSSOM NOACIP NOACIP RITEFLOX RITEFLOX CIPCARE CIPCARE QUINOCIP QUINOCIP POROX POROX AWACIP RACIP RACIP CIP-RX CIPREX CIPREX CIPROCURE CIPROCURE CIPROCURE CIPROCURE CIPROCURE NOVICIP NOVICIP CIPROLIVE CIPROLIVE Q-CIP Q-CIP CIPROYAN CIPROYAN CIPROFOZ CIPROFOZ CIPROLOX CIPROLOX CIPROFAZ CIPROFAZ E-LOX E-LOX GLIROX GLIROX GLIROX GLIROX JAWAFLOX JAWAFLOX QINFLOX QINFLOX NOVIDAN NOVIDAN DANPRO DANPRO ORUXIN ORUXIN CIPROL CIPROL BACK-ON CURABID CURABID BACIDAL BACIDAL ARIFLOX ARIFLOX CIPROSOL I.V MARFLOX MARFLOX MARFLOX CIPROZEE CIPROZEE QEVO QEVO CIPROJAN CIPROJAN CIPROJAN CIPROJAN CIPORAINS LONOCIP LONOCIP WEBCIN WEBCIN WEBCIN WEBCIN WEBCIN CHOIX CHOIX PROFOX PROFOX PROFOX CIPFEN GRAYCIP CIPROGRAY CIPROGRAY CIPXRE CIPXRE NEXCIP NEXCIP NEXCIP NEXCIP STERICIPRO ANCIP ANCIP TEROX TEROX BANXIN BANXIN MAKCIP XR MAKCIP XR NEOAGE NEOAGE ALIPRO ALIPRO DICIP LIGCY QUINOMAX QUINOMAX ANTICIP MEDIPROX MEDIPROX C-PROX C-PROX C-PROX C-PROX C-PROX C-PROX WINFLOX WINFLOX WINFLOX SLEXIA CIPROWIN CIPROWIN SUPERCIPRO SUPERCIPRO PIROCAP PIROCAP PIROCAP PIPROCAP PIPROCAP BI CIP BI CIP BI CIP BI CIP MEGACIP TABLET MEGACIP TABLET XPRO XPRO CAPARO CAPARO ROPCI ROPCI HEPRO HEPRO SACIP SACIP ZEPRO TABLET ZEPRO TABLET CIPRULZ CIPRULZ CIPRULZ CIPRULZ HAMPRO HAMPRO CARALOX CIPTOP CIPTOP CIPTOP CIPTOP CIPTOP CIPCAP CIPCAP FLOCIPRIN FLOCIPRIN FLOROCIP FLOROCIP CIPROGOOD CIPROGOOD CIPROGOOD LOTOCIP LOTOCIP LOTOCIP LOTOCIP CIPROWN MONARC MONARC MONARC VAPEN VAPEN AMROQUIN AMROQUIN CIPRON CIPRON NEEDOX CIPSER QUIXOR FORTE ZYFLO ZYFLO CIPROLEY CIPROLEY CIPWEL CIPWEL AMPROX AMPROX CIPVAX CIPFAZ CIPFAZ CIPFAS CIPFAS CIPROTEK CIPROTEK CIPROTEK CIPROSE CIPROSE CIPROSE CIPROSE CIPROWAN CIPROWAN CIPOCIN CIPOCIN CIPROGAT CIPROGAT CIPROGAT CIPROGAT CIPROGAT SCANLUX SCANLUX SCANLUX HUFCIN HUFCIN MAXCIP MAXCIP WELCIP Q-FLOX FLOX WEL PRO-HIT PRO-HIT CIPROWRD CIPROWRD CEBECT CEBECT STYX SENTRA CIPWARI CIPWARI CIPROFOLD CIPROFOLD KAPROCIN KAPROCIN FINECIP FINECIP CIPROFAST CIPROGIL CIPROGIL CIPSET CIPSET OCUCIP TABLET OCUCIP TABLET OCUCIP INFUSION SAYFLOXINE SAYFLOXINE SAYFLOXINE XOCIP XOCIP EXICPRO EXICPRO TOPCIP TOPCIP NUCIP NUCIP CRESCIP CRESCIP CIPROJECT CIPROJECT CIPROZAN CIP SUSPENSION GT-CIP XL GT-CIP XL GT-CIP GT-CIP CURECIP QUINODEX ZEPRO SUSPENSION ZEPRO SUSPENSION GOODCIP GOODCIP DOMAX CIPRAYS MYROBECT CIPROZIP CIPROZIP WARFLOX WARFLOX BINCIP CIBRAIN CIBRAIN CIPRACY CIPRACY CIPROTEL CIPRON TRICIP TRICIP APTICIP APTICIP CIPOTENT CIPOTENT KANCIP KANCIP A-CIP A-CIP A-CIP A-CIP NIXIN CIPREXIS CIPREXIS CIPREXIS CIPOSIM CIPOSIM CIPOSIM CIPOSIM CIPESTA CIPESTA CIPESTA CIPESTA CIPESTA CIPESTA CIPESTA CIPESTA CIPROFRED CIPROFRED

Dose: 100 to 400 mg
Single Dose: 250 (250)
Frequency: 12 hourly
Route: IV
Instructions: As required. Usually for 5-7 days.

Ciprofloxacin (HCl) is the derivative of Ciprofloxacin. It is of Semi Synthetic origin and belongs to Quinoline Carboxylic Acid. It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Ciprofloxacin is 346.00. Its pKa is 6-8.8.

Ciprofloxacin is contraindicated in conditions like Epilepsy,Hypersensitivity.

The severe or irreversible adverse effects of Ciprofloxacin, which give rise to further complications include Pseudomembranous colitis, Hearing loss, Seizures.Ciprofloxacin produces potentially life-threatening effects which include Anaphylactoid reactions, Stevens Johnson syndrome, Acute Renal Failure, Fluminant hepatic failure, Epidermal necrolysis. which are responsible for the discontinuation of Ciprofloxacin therapy.The symptomatic adverse reactions produced by Ciprofloxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Tachycardia, Nervousness, Termors, Rashes, Urticaria, Pruritus, Photosensitivity, Elevation of liver enzymes, Thrombocytopenia, Eosinophilia, Increased intracranial pressure, nervousness, joint symptoms, agranulocytosis.

Ciprofloxacin is primarily indicated in conditions like Acromegaly (short-term treatment before pituitary surgery), Chronic prostatitis, GI infections, Gonorrhoea, Iron-deficiency anaemia prophylaxis or for mild iron deficiency, Iron-deficiency anaemia with chronic renal failure, Most other infections, Muscle relaxation (long duration) for surgery and intubation, Muscle relaxation for surgery or intubation, Osteomyelitis, Pseudomonal lower+RTI in cystic fibrosis, Respiratory tract infections, Sexually transmitted disease, Sexually transmitted infections, Skin infections, Skin structure infections, Status epilepticus (unlicensed use), Surgical prophylaxis, Urinary tract infection.

Ciprofloxacin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCaffeineCoadministration inhibit the metabolism of caffeine thus increasing its plasma concentration and pharmacological effect.Ciprofloxacin increases caffeine AUC by 50% to over 100% and reduces its clearance upto 50%.ModerateCaffeine intake should be avoided during treatment that may increase the risk of adverse effects like tremor,insomnia,tachycardia and blood pressure.Calcium Carbonatebinds with drugs or increase pH that effects drug solubilityantacid should not be given within two hours of the dose of these drugsChloramphenicolClozapineCoadministration increases the plasma concentration of clozapine by inhibiting CYP450 1A2 responsible for metabolic clearance of clozapine.ModeratePharmacological response and plasma clozapine concentration should be monitored closely.Cyclosporin ACiprofloxacin increases the serum concentration of cyclosporin. The risk of cyclosporine induced neurotoxicity and nephrotoxicity may also be increased.ModerateCyclosporine levels and renal function must be closely monitored.Insulin Lispro ProtamineMagnesium Oxides and HydroxidesMagnesium hydroxides and aluminium hydroxide antacids, iron, calcium, zinc containing products impair absorption of ciprofloxacin.Mangnese Glycerophosphate Mangnese decreases effectiveness of Quinolone antibioticsModerateTake manganese supplements at least one hour after antibiotics.MethotrexateCiprofloxacin increases the plasma concentration of methotrexate by competitively inhibiting renal tubular secretion of methotrexate result in severe toxicity.ModerateConcomitant use of these drugs considered contraindicated. Closely monitor for altered pharmacologic effects. Adjust the dose if necessary.Multiple VitaminsConcurrent use may decrease the absorption of Ciprofloxacin.Separate your doses of Ciprofloxacin as far as possible from doses of multi vitamins.NaproxenPiperazine ring of ciprofloxacin inhibits the binding of GABA to brain receptors and naproxen synergistically add to this effect thus increase the risk of CNS stimulation and convulsion.ModerateClose monitoring of CNS stimulation is advised.PentostatinConcurrent use may reduce the plasma concentrations of oral quinolone antibiotics.MinorDuring concomitant use with chemotherapeutic agents, patient response to quinolone therapy should be monitored and the dosage of antibiotic adjusted accordingly if necessary.Phenytoin (Na)Ciprofloxacin may either increase or decrease the plasma concentration of phenytoin, thus increasing the risk of phenytoin toxicity or seizure.ModerateClosely monitor the plasma concentration of phenytoin whenever start or discontinue ciprofloxacin. Adjust the dose of phenytoin accordingly.PomalidomidePomalidomide exposure is increased co-administered with ciprofloxacinAvoid co-administration, if medically necessary Pomalidomide dose should be reduced by 50%.ProbenecidProbenecid decreases the urinary excretion of ciprofloxacin thus increases its plasma concentration.MinorRifampicinRifampin induces the metabolism of ciprofloxacin.Rutin (Vitamin P)Rutin may competitively inhibit action of Ciprofloxacin.Sevelamer HClsevelamer hydrochloride decreased the bioavailability of ciprofloxacin by approximately 50%.Should not be taken simultaneously with ciprofloxacinSucralfateTheophyllineCiprofloxacin enhances the serum level of theophylline by inhibiting its metabolism and by reducing its clearence upto 65% may result in increased risk of toxicity. Concomitant use of theohylline with interavenous ciprofloxacin may results cardiac arrest, seizure,status epilepticus and respiratory failure.MajorConcomitant use should be avoided. Closely monitor the pharmacologic response and serum level of theophylline whenever start, discontinue or change the dose of ciprfloxacin.Patient should notify the symptoms of theophylline toxicity.Warfarin (Na)Ciprofloxacin potentiate the hypoprothrombinemic effect of warfarin by inhibiting its metabolism and depleting certain clotting factors due to suppression of vitamin-k producing intestinal flora.MajorINR should be checked frequently and dose of warfarin should be adjusted whenever start or discontinue quinolone therapy. Patient should report any sign of bleeding to doctor. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Elevations of SGPT and SGOT Serum creatinin raisedElevation in ALT or ASTblood urea raised

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Eye Soln/ Eye ointment Store at room temperature, Below 30°C or in refrigerator. Do not Freeze. Protect from Sunlight. Inj (reconstituted soln) Store at room temperature, Below 25°C or in refrigerator. Do not Freeze. Protect from Sunlight. Use within 2 weeks if kept at room temperature. Store .

Ciprofloxacin should be used with caution in patients with known or suspected central nervous system (CNS) disorders, renal impairment or hepatic disease, with a history of GI disease especially colitis or who have dehydration. Do not exceed the recommended dose. Take appropriate measures if secondary infections occur.