ADVANTAN ADVANTAN ADVANTAN ADVANTAN ADVANTAN FATTY ADVANTAN FATTY CO-STEROL AVATE AVATE SOLU MEDROL SOLU MEDROL SOLU MEDROL SOLU MEDROL DEPO MEDROL DEPO MEDROL METHYPRED METHYPRED CETA-MEDROL CETA-MEDROL

Dose: 0.5 to 2 g
Single Dose: 1.2 (1.25)
Frequency: 24 hourly
Route: IV,IM
Instructions: For 3 days

Methylprednisolone also known as Methylprednisolone (actate). Methylprednisolone (Na Succinate), Methylprednisolone (Na Succinate) are the derivatives of Methylprednisolone. It is of Synthetic origin and belongs to Glucocorticoid. It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Dermatological Products and Corticosteroid Topical pharmacological group.The Molecular Weight of Methylprednisolone is 496.50.

'Methylprednisolone is contraindicated in conditions like Cerebral oedema,Cushing''s syndrome,Fungal infection,Peptic ulcer,Psychosis,Viral infection,Herpes simplex keratitis,Syphilis,Tuberculosis,Hypersensitivity,Varicella,Vaccinia.'

The severe or irreversible adverse effects of Methylprednisolone, which give rise to further complications include Hypercalciuria, Congestive heart failure, Telangiectasia, Glaucoma, Cataract, Insomnia, Fluid retension, CHO intolerance, Peptic ulceration, Hypertension, Osteoporosis, Growth retardation, Aseptic bone necrosis, Viral infections, Cataract, Hypercalciuria, Hypokalemic alkalosis, Hemorrhages, Mood swings, Acute psychosis, Loss of matrix.Methylprednisolone produces potentially life-threatening effects which include Cardiac arrhythmias, Hypotension, Cardiac Arrest, Cardiac arrest, Bronchospasm, Bronchospasm, Anaphylactic reactions, Cardiovascular collapse. which are responsible for the discontinuation of Methylprednisolone therapy.The signs and symptoms that are produced after the acute overdosage of Methylprednisolone include Hyperglycemia, Hyperuricemia.The symptomatic adverse reactions produced by Methylprednisolone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Erythema, Itching, Burning, Acneform, Folliculitis, Striae, Hypertrichosis/gingival hypertrophy, Fragility of skin, Menstrual irregularity, Facial erythema, Perioral dermatitis, Allergic skin reactions, Cushing syndrome, Hypopigmentation, Hyperpigmentation, Ecchymoses, Thin skin, Proximal myopathy, Skin atrophy, Vesiculation, Skin Atrophy, hypopigmentation.

'Methylprednisolone is primarily indicated in conditions like Allergy, Angioneurotic edema, Asthma, Autoimmune disease, Collagen disease, Crohn''s disease, Dermatological diseases, Eczema, Endocrine disorder, GI diseases, Graft rejection, Leukaemia, Lymphoma, Multiple sclerosis, Nephrotic syndrome, Ocular inflammation, Opthalmic disease, Rejection of organ transplants, Renal diseases, Termination of pregnancy of 13-24 weeks gestation, Traumatic injury, Ulcerative colitis.'

Methylprednisolone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmphotericin BConcomitant use can lead to hypokalemiaAspirinMethyl prednisolone decreases the serum concentration and thus therapeutic effects of salicylates by increaseing renal clearence and inducing hepatic metabolism.ModerateMedications should be taken with food and immediately report the sign and symptoms of GI ulceration and bleeding.AspirinCarbamazepineCarbamazepine accelerates metabolism of Corticosteroids (reduced effect).MajorCarbamazepineCyclophosphamideCyclosporin AConcomitant use can lead to convulsionsCyclosporin AErythromycinErythromycin by interfering in hepatic and intestinal metabolism increases blood concentration of cyclosporine through CYP450 3A4 inhibition and may result in nephrotoxicity and neurotoxicity.ModerateGenerally avoid.Adjust dose and check cyclosporine blood levels and renal function.ErythromycinEstrogens ConjugatedGlibenclamideSteroids (e.g Methylprednisolone) induced hyperglycemia may partially antagonize the effect of hypoglycemic drugs (e.g Glibenclaimide)LofexidineTheoretical potential for METHYLPREDNISOLONE reducing the HYPOTENSIVE effect of LOFEXIDINE HYDROCHLORIDE. ModerateMetyrosineTheoretical potential for METHYLPREDNISOLONE reducing the HYPOTENSIVE effect of METIROSINE. ModeratePhenobarbitoneBarbiturates (e.g. Phenobarbitone ) can increase metabolism of methyl prednisolonePhenytoin (Na)Pyridostigmine (Br)coadministration with corticosteroids such as methylprednisolone result in profound weaknessventilationRifampicinRotavirus vaccineThe administration of live, attenuated virus or bacterial vaccines during immunosuppressant or intense antineoplastic therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. Patients may be immunosuppressed if they have recently received Methylprednisolone.ModerateIn general, live virus or bacterial vaccines should not be used in patients receiving Methylprednisolone.Tacrolimus These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Antigen Skin Test ACTH Stimulation testACTH stimulation test

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab,Inj Store Between 15°C-30°C. Do not Freeze. Protect from Sunlight and Moisture.

Do not have a vaccination, other immunization or any skin test while taking methylprednisolone unless doctor specifically recommended. Avoid use this drug during pregnancy or lactation. This can cause growth suppression in infants, so avoid use. It should be used with caution in patients with liver, kidney, intestinal or heart disease, hypothyroidism, high blood pressure, myasthenia gravis, osteoporosis (brittle bones), herpes eye infection or history of tuberculosis (TB), seizures, ulcers or blood clots. It should be used with caution if patient have a history of ulcers or take large doses of aspirin or other arthritis medication or use alcoholic beverages, because it may make stomach and intestines more susceptible to the irritating effects of alcohol, aspirin and certain arthritis medications, increasing risk of ulcers. Consult the doctor about any injuries or signs of infection (fever, sore throat, pain during urination and muscle aches) that occur during treatment and within 12 months after treatment with this drug, the dose may need to be adjusted or may need to start taking the drug again. It should be used with caution in patient with diabetes, because this drug may increase blood sugar level, test urine for sugar (glucose) frequently and contact the doctor if sugar is present, the dose of diabetes medication and diet may need to be changed.