Debrisoquine (Sulphate)

Chemically Debrisoquine (Sulphate) is 3, 4-dihydro-2(1H)-isoquinolinecarboxamidine. Debrisoquine (Sulphate) is adrenergic neurone blocking agent. Debrisoquine (Sulphate) is used in hypertension to lower the blood pressure.


Adult Dose
Dose: 0.143 to 0.285 mg/kg
Single Dose: 0.21 (0.214)
Frequency: 24 hourly
Route: PO
Instructions: Initial
Neonatal
Paedriatic
Characteristics
Debrisoquine (Sulphate) also known as Isocaramidine Sulphate. . It is of Synthetic origin and belongs to Isoquinoline. It belongs to Antihypertensive Agents pharmacological group.The Molecular Weight of Debrisoquine (Sulphate) is 448.50. Its pKa is 11.9.
Contraindications
Debrisoquine (Sulphate) is contraindicated in conditions like Phaeochromocytoma,Renal failure.
Effects
Debrisoquine (Sulphate) produces potentially life-threatening effects which include Blood pressure reduction. which are responsible for the discontinuation of Debrisoquine (Sulphate) therapy.The signs and symptoms that are produced after the acute overdosage of Debrisoquine (Sulphate) include Orthostatic hypotension.The symptomatic adverse reactions produced by Debrisoquine (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Syncope, Failure of ejaculation.
Indications
Debrisoquine (Sulphate) is primarily indicated in conditions like Hypertension, and can also be given in adjunctive therapy as an alternative drug of choice in Amoebic dysentry, Granulomatous disease, Skin lesions.
Interactions
Debrisoquine (Sulphate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholAmitriptyline (HCl)Chlorpromazine (HCl)Desipramine (HCl)Dothiepin (HCl)Doxepin (HCl)Imipramine (HCl)Lofepramine (HCl)Theoretical potential for LOFEPRAMINE reducing the HYPOTENSIVE effect of DEBRISOQUINE. Noradrenaline (Acid Tartrate)Phenylpropanolamine (HCl)Trimipramine (Maleate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container. Protect from Sunlight.
Warnings
Take this medication as directed by physician. Take no more of the medication than the amount prescribed. Take with food to minimize possible gastrointestinal irritation.
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