Betamethasone

Betamethsone is a synthetic glucocorticoid, the most active of the anti-infalammatory steroids, used topically as an anti-infalmmatory and administered orally as a replacment therapy for adrenal insufficiency.


Brands
ANGLOSONE ANGLOSONE BETADERM BETADERM BETADERM BETADERM BETADERM BETADERM-NM BETADERM-N BETADERM-N BETADERM-N BETADERM-N PROBETA-N PROBETA-N BETACIN-N BETACIN-N BETACIN-N BETACIN-N BETNELAN BETNESOL BETNESOL BETNESOL BETNESOL BETNESOL-N BETNESOL-N BETNOVATE BETNOVATE BETNOVATE BETNOVATE BETNOVATE BETATEK BETATEK-N NOVOVATE-N NOVOVATE-N NOVOVATE-N NOVOVATE-N NEOSONE DIPROCORT DIPROCORT DIPROCORT GENTICYN-B PROVATE PROVATE PROVATE PROVATE-G PROVATE-G PROVATE-S PROVATE-S REKABSON-N SEMOVET-N BETNOCIN BETNOCIN ORBETAM ORBETAM ORBETAM ORBETAM-N ORBETAM-N ORBETAM-N FUCICORT BETNOVATE-N BETNOVATE-N BETNOVATE-N BETNOVATE-N BETNOVATE-N BETNOVATE-N BETNOVATE-N PRO-ONE GEL BETADROP-N BETADROP-N BEPROGENT BEPROSALIC BEPROSONE BETANATE BETASALY BETASALY BETAVAL BETAVAL BETAVAL BETAVAL BETAMETHASONE BETAMETHASONE BETAGENT BETAGENT BETAGENT FOSEDIC-B FOSEDIC-B DIPROCORT-S DIPROCORT-S MICOGEN-B DIPROSAN BETONIL AUSTASONE AUSTASALIC BETADIP BETADIP BETAGENIC BETASALIC PROBETA BETACORT BETACORT BETACORT-N BETACORT-N BETACORT-N BETACORT-N CENOVATE-N CENOVATE-N CENOVATE-N CENOVATE-N CENOVATE-N NEOBETA NEOBETA DE-SONE HYPROLENE MYSODERM BETAZOLE BETAZOLE DIGENT VALIGENT FUSIL-B FUSIL-B BETACIN BETACIN BETACIN BETACIN BETACIN PLUS BETACIN PLUS BETACIN PLUS BETACIN PLUS DERMODIC-B DERMODIC-B LOTRICORT ZUDICORT ZUDICORT AUSTAGENT DIPROCORT G EFFIDEX EFFIDEX EFFIGENTA EFFIGENTA NOVASALIC SALODERM SALODERM BETAVAL-N BETAVAL-N BETAVAL-N BETAVAL-N BETAVAL-N REKABSON DISON DIPGEN DIPSAL DIPSONE FU-SKIN B FU-SKIN B SPECTRAZOLE SPECTRAZOLE SPECTRAZOLE BETGENT BETGENT BETONIL-N BETONIL-N BETAREX BETAREX BETAREX-N SALINOSE ETNESOL N EUROSONE EUROSONE EPONIX-G EPONIX-G DERMOVAL DERMOVAL DAIVOBET BETHAZONE-N UNISALIC DIPROGENTA DIPROGENTA BETASKIN N CLORAZIDE BETASOL BETASOL N BETASOL N BEVA-N BEVA-N BEPRONATE BETAMYCIN DERMOGENT DERMOSALIC EPONIX-S EPONIX-S SIDICORT BETASPORIN BETASONE N BETASONE N BETNOCIN N BETNOCIN N METHANATE-G METHNATE-S HYDROMYCIN-B LOTRICORT G LOTRICORT G MONFUSI B ENCORE ENCORE ENCORE ENCORE G ENCORE G ENCORE S ENCORE S FUSIMIN B METHAVAL METHANATE METHANATE S PROCORT PROCORT PROCORT BETAWIS G BETAWIS G DANOVATE-N DANSONE DANSONE VIO BET N VIO BET N VIO BET N VIO BET N PRO ONE SONATE N SONATE N BIOSONE SA SONATE SONATE PROCORT G SIDIK B CALCIBET MYCONA-GB UDIC-B SECODIC B BIOZON BIOZON BIOZON BIOZON BIOZON BIOZON BIOZON BIOZONE N BIOZONE N BIOZONE N BIOZONE N GENIDIC -B TRI-GMB TADIC CLOMISONE FUCIROG-B BESOL-N DROP BIMOLE FUDELUX B BENATE BESALIC BETAWIS BETAWIS DIPROCORT-C DIPROCORT-C FUSIWAY-B GENB GENB B-GEN B-GEN B.M.T. BECLIC BEONE BEONE PLUS BETHAHEAL BETHAHEAL BIOSALIC DERVIT-B GENBET HAMETH MUPROCIN NATABON POTRIOL-B PROVAT-C PROVAT-C SALISONE-G TECHNOBET TECHNOBET TECHNOBET G TECHNOBET-S SPECTRAZOL-G WEBNATE WEBNATE WEBNATE ZYNNOVATE PROVATE-C DERMOSPORIN-B BETAMET DIODERM USIBET BENASOL N
Adult Dose
Dose: 4 to 20 mg
Single Dose: 12 (12)
Frequency: As recommended.
Route: IV
Instructions: At affected area only .
Neonatal
Paedriatic
Dose: 0.2 mg/kg
Single Dose: 0.2 (0.2)
Frequency: 8 hourly
Route: IV
Instructions:
Characteristics
Betamethasone also known as Betamethasone -17-valerate. Betamethasone (Valerate), Betamethasone (Valerate), Betamethasone (Valerate) are the derivatives of Betamethasone. It is of Synthetic origin and belongs to Steroid. It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Dermatological Products and Corticosteroid Parenteral pharmacological group.The Molecular Weight of Betamethasone is 392.46.
Contraindications
Betamethasone is contraindicated in conditions like Herpes simplex infections,Acne vulgaris,Rosacea,Perioral dermatitis,Hypersensitivity,Napkin eruption,Perioral pruritus,Genital pruritus,Gravitational ulceration,Infestations,Skin lesions.
Effects
The severe or irreversible adverse effects of Betamethasone, which give rise to further complications include Atrophy, Steroid purpura, Steroid purpura, Skin fragility, Angioedema, Perioral dermatitis.Betamethasone produces potentially life-threatening effects which include Cushing`s syndrome, Diabetes, Hypertension, Growth suppression. which are responsible for the discontinuation of Betamethasone therapy.The signs and symptoms that are produced after the acute overdosage of Betamethasone include Convulsions, Electrolyte imbalance, Abdominal distension.The symptomatic adverse reactions produced by Betamethasone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Headache, Diarrhea, Fever, Anxiety, Constipation, Abdominal pain, Sweating, Erythema, Hypotension, Arthralgia, Acne, Hypersensitivity reactions, Menstrual irregularity, Cataract, Hypertrichosis, Pigmentation, Superficial blood vessels dilatation, Local hypopigmentation, Superficial blood vessels thinning, Peptic ulcer, Skin thinning, Subcutaneous atrophy, ocular changes.
Indications
Betamethasone is primarily indicated in conditions like Allergy, Asthma, Contact sensitivity reactions, Dermatitis, Discoid lupus erythematosus, Eczema, Inflammation, Insect bite reactions, Keloid scarring, Lichen planus, Localized bullous disorders, Neurodermatoses, Photosensitivity, Pretibial myxoedema, Pruritus, Psoriasis, Seborrheic dermatitis, Skin diseases, Strains.
Interactions
Betamethasone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmphotericin BIncreased risk of hypokalemia when corticosteroids (e.g Betamethasone) given with Amphoteracin B. ADVICE: Avoid concomitant use unless Amphotericin needed to control reactions.MajorCarbamazepineMetabolism of corticosteroids (e.g Betamethasone) possilbly enhanced by Carbamazipine (reduced effect). MajorIndacaterolConcomitant therapy may increase the risk of hypokalemia monitor closelyLofexidineTheoretical potential for BETAMETHASONE reducing the HYPOTENSIVE effect of LOFEXIDINE HYDROCHLORIDE. ModerateMetyrosineTheoretical potential for BETAMETHASONE reducing the HYPOTENSIVE effect of METIROSINE. ModerateOxandroloneThe concomitant administration of oxandrolone and adrenal cortical steroids may increase the edema in patients with edema. The mechanism and clinical significance are unknown. Closer monitoring may be appropriate, especially in patients with conditions that may be aggravated by fluid retention.MinorPerindoprilTheoretical potential for BETAMETHASONE reducing the HYPOTENSIVE effect of Perindopril Erbumine. ModeratePhenytoin (Na)Metabolism of corticosteroids (e.g Betamethasone) possibly accelerated by Phenytoin (reduced effect).MajorRifampicinRifampicin reduce activity of corticosteroids by accelerating metabolism of betamethaosoneDose reduction is necessary These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 30°C. Do not Freeze. Protect from Sunlight. Tab, Oint, Gel, Cream, Lotion, Oral Soln Store in a well closed container, at room temperature, Below 30°C or in refrigerator. Do not Freeze. Protect from Sunlight.
Warnings
Betamethasone should be used with caution in patients with active tuberculosis infection of respiratory tract or in untreated fungal, bacterial or systemic viral infections. Corticosteroids should only be used systemically with great caution in the presence of congestive heart failure (CHF), recent myocardial infraction (MI), hypertension, diabetes mellitus, epilepsy, glaucoma, hypothyroidism, liver failure, osteoporosis, peptic ulceration or renal impairment. Children may be at increase risk of some adverse effects, corticosteroid causes growth retardation and prolonged use is rarely justified. Passive immunization is recommended to non-immune patients who do come in contact with chickenpox or measles. Live vaccine should not be given to patients receiving high dose systemic corticosteroid therapy nor for atleast 3 months afterwards, killed vaccine or toxoids may be given, although the response may be attenuated. During prolong treatment with corticosteroids, patients should be examined regularly, sodium intake may need to be reduced and calcium and potassium supplement may be necessary. Patient should carry cards given full details of their corticosteroid therapy. Avoid use during pregnancy. Use nasal steroids with caution until healing has occurred.Long-term therapy should be avoided espacially in infants and children as adrenal suppression may occur. Care should be taken so that the prepation does not enter the eyes as glucoma may result. In secondary infected lesions antimicrobial therapy should be used in cases of spread of infection, topical steroid therapy, should be stopped. prolong aaplication on the face should be avoided.
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