Dapsone

Dapsone is an antibacterial agent. It acts as a bacteriostatic for a broad spectrum of gram negative and gram positive organisms. Dapsone is effective in treating leprosy and other skin conditions, malaria, arthritis, other inflammatory conditions and also in pneumocystis pneumonia. Dapsone is administered orally.

Brands
DERMOSONE DAPSIN DAPSIN
Adult Dose
Dose: 50 to 100 mg
Single Dose: 75 (75)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 50 mg/kg
Single Dose: 50 (50)
Frequency: 24 hourly
Route: Oral
Instructions:
Characteristics
Dapsone also known as Diaphenylsulfone, Diaphenylsulfone. Biogen is the derivative of Dapsone. It is of Synthetic origin and belongs to Sulfonylbenzeamine. It belongs to Dihyropteroate synthetase inhibitor pharmacological group on the basis of mechanism of action and also classified in Leprostatics pharmacological group.The Molecular Weight of Dapsone is 248.30. Its pKa is 1.3-2.5.
Contraindications
Dapsone is contraindicated in conditions like Anaemia,G6pd deficiency,Porphyria,Sulfone allergy.
Effects
The severe or irreversible adverse effects of Dapsone, which give rise to further complications include Hepatitis, Nephrotic syndrome, Peripheral neuropathy, Psychosis, Depression, Methemoglobinemia, Sulfhemoglobinemia, Anaemia.Dapsone produces potentially life-threatening effects which include Agranulocytosis, Severe hemolytic anemia, Dapsone syndrome. which are responsible for the discontinuation of Dapsone therapy.The signs and symptoms that are produced after the acute overdosage of Dapsone include Nausea, Vomiting, Coma, Jaundice, Abdominal pain, Methemoglobinemia, Severe hemolytic anemia.The symptomatic adverse reactions produced by Dapsone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Anorexia.
Indications
Dapsone is primarily indicated in conditions like Dermatitis herpetiformis, Leprosy, Malaria prophylaxis, Pneumocystis carinii pneumonia prophylaxis, and can also be given in adjunctive therapy as an alternative drug of choice in Actinomycotic mycetoma, Autoimmune thrombocytopenic purpura, Cutaneous leishmaniasis, Idiopathic skin conditions, Metastatic germ cell cancer, Pneumocystis carinii pneumonia, Relapsing polychondritis, Rheumatoid arthritis, Squamous cell carcinoma, Systemic lupus erythematosus.
Interactions
Dapsone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmprenavirAmprenavir possibly increases plasma concentration of Dapsone.MajorCimetidine (HCl)ClofazimineDidanosineEstrogens ConjugatedBroad spectrum antibacterials (e.g.Dapsone) possibly reduce contraceptive effect of Estrogens.Risk probably small.MajorProbenecidExcretion of Dapsone reduced by Probenecid (Increased risk of side effects).ProbenecidPyrimethamineRifampicinRifampicinTrimethoprimVORICONAZOLEVoriconazole may increase the serum concentration of dapsone by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of dapsone if voriconazole is initiated, discontinued or dose changed. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, at room temperature. Protect from Sunlight.
Warnings
Dapsone should be used only if clearly needed during pregnancy. Dapsone is not recommended during lactation. It should be used with caution in patients with any pre-existing blood disorders, liver disease, kidney disease, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency or allergies.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.