Dose: 0.357 to 5.714 mg/kg
Single Dose: 3 (3.0355)
Frequency: As recommended.
Route: PO
Instructions: Per Week for 7 Weeks.

Dose: 500 mg/kg
Single Dose: 500 (500)
Frequency: 1 hourly
Route: Increased gradually if necessary to 2mg/kg 3 or 4 times daily but a dose of 100 mg 4 times a daily
Instructions:

Dantrolene sodium is the derivative of Dantrolene (Na). It is of Synthetic origin and belongs to Imidazolidinedione. It belongs to Muscle Relaxants pharmacological group.The Molecular Weight of Dantrolene (Na) is 337.00. Its pKa is 7.5.

Dantrolene (Na) is contraindicated in conditions like Hepatic dysfunction,Spasticity of functional use,Muscle spasm in rheumatic conditions.

The severe or irreversible adverse effects of Dantrolene (Na), which give rise to further complications include Diarrhoea, Tachycardia, Pleural effusion, Seizures, Depression, Urinary retention, Pericardial effusions, Intestinal obstruction, Hematuria, Exacerbation of seizures, Unsatable BP, Urinary retention.Dantrolene (Na) produces potentially life-threatening effects which include Hepatotoxicity, Pleural effusion with pericarditis. which are responsible for the discontinuation of Dantrolene (Na) therapy.The signs and symptoms that are produced after the acute overdosage of Dantrolene (Na) include Unconsciousness, Paralysis of skeletal muscles.The symptomatic adverse reactions produced by Dantrolene (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Drowsiness, Fatigue, Nausea, Vomiting, Anorexia, Abdominal cramps, Constipation, Insomnia, Nervousness, Chills, Confusion, Pruritus, Malaise, Muscle weakness, Vision disturbances, Confusion, nervousness, Nervousness, dizziness.

Dantrolene (Na) is primarily indicated in conditions like Chronic and severe spasticity, Malignant hyperthermia, Neuroleptic malignant syndrome, Prostate cancer, long-term palliative therapy, Tetanus.

Dantrolene (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholVerapamil (HCl)VORICONAZOLEVoriconazole may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therap These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

changes in ECG & serum electrolytes

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps Store in a well closed container, Below 40°C. Protect from Moisture and Heat.

Dantrolene should be used with caution in patients with impaired pulmonary function, cardiac disease or liver disease. Patient should observe caution while driving or performing other tasks requiring alertness. Photosensitization occurs, so caution patient to take protective measures (sunscreen etc.) against exposure to UV or sunlight.