Danazol

Danazol is an isoxazole derivative of ethisterone (17a-ethinyl testosterone). It has weak progestational and androgenic activities. It is a synthetic androgen (hormone). itused to treat pain and infertility caused by endometriosis (a condition involving the tissue of the uterus). italso used in the treatment of cysts or lumps in the breast.

Brands
DANZOL DANZOL DANOCRINE DANOCRINE DANOCRINE DANOCRINE LOZANA DANATRIS DANATRIS DANATRIS DANATRIS
Adult Dose
Dose: 200 to 500 mg
Single Dose: 350 (350)
Frequency: As recommended.
Route: PO
Instructions: given in 2 divided doses daily for 3-6months.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 10 to 40
Single Dose: 25 (25)
Frequency: 24 hourly
Route: Oral
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Steroid. It belongs to Aldosterone agonist pharmacological group on the basis of mechanism of action and also classified in Sex Hormones and Androgen pharmacological group.The Molecular Weight of Danazol is 337.50.
Contraindications
Danazol is contraindicated in conditions like Vaginal bleeding,Thrombo-embolic complications,Porphyria.
Effects
The severe or irreversible adverse effects of Danazol, which give rise to further complications include Hirsutism.Danazol produces potentially life-threatening effects which include Hepatic peliosis, Hepatic dysfunction. which are responsible for the discontinuation of Danazol therapy.The symptomatic adverse reactions produced by Danazol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Sweating, Weight gain, Edema, Hot flushes, Acne, Amenorrhea, Hair growth, Oily skin.
Indications
Danazol is primarily indicated in conditions like Benign breast disease, Endometriosis, Gynaecomastia, Long term management of hereditary angioedema, Menorrhagia, Premenstrual syndrome, Severe pain and tenderness in benign fibrocystic breast disease, Treatment of endometriosis, and can also be given in adjunctive therapy as an alternative drug of choice in Angioedema, Idiopathic thrombocytopenic purpura.
Interactions
Danazol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholsubjective intolerance in the form of nausea and dyspnea may occurAlfacalcidolpotentiate hypercalcemiaBovine InsulinCarbamazepinedanazol inhibit the metabolism of cabamazepine ( other anti convulsant drug include phenobarbital) (increased risk of toxicity).MajorCyclosporin ADanazol can increase plasma concentration of cyclosporinHuman Insulindanzaol increase insulin resistancepatient should be carefully monitoredInsulin GlulisineDanazol, corticosteroids, niacin, diuretics, sympathomimetic agents (e.g., epinephrine, albuterol, terbutaline), phenothiazine derivatives, thyroid hormones, progestogens (e.g., in oral contraceptives), protease inhibitors, and atypical antipsychotics may reduce the blood-glucose-lowering effect.Insulin LisproProgesteronedanazol acts by binding to estrogen , progesterone or androgen receptor at various levels in the hypothalamic pituitary ovarian axis. danazol may compete for binding sites.SimvastatinConcomitant administeration can lead to RhabdomyolysisTacrolimusWarfarin (Na)co administration result in increase prothrombin time . danazol can significantly increase the hypoprothrombinemic action of oral anticoagulants by reducing the vitamin k available for metabolic competition with the anticoagulant. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Interferes with Thyroid Function Test
Risks
Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Danazol should not be used during pregnancy or lactation. It should be usedwith caution in-patients with migraine headaches, heart, liver or kidney disease, a history of seizures, breast cancer, abnormal bleeding, previous strokes, prostate cancer or any other diseases. Extreme caution is advised for use in children. Pediatric specialist consultation is also advised. Geriatric men are at increased risk of developing enlarged prostate and prostate cancer with the use of androgen-like drugs, so use cautiously.
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