Dacarbazine

Dacarbazine is an antineoplastic drug. Dacarbazine is a synthetic compound that functions as an alkylating agent. All alkylating agents have or can form an alkyl group that becomes covalently bound to cellular constituents. Dacarbazine is effective in the treatment of different cancers to slow or stop the growth of abnormal or cancerous cells. Dacarbazine is used in combination with different anticancerous drugs to obtain excellent therapeutic effects and to minimize unwanted effects or toxicities.

Brands
DUTICIN DARBAZINE DACARBAZIN DAC
Adult Dose
Dose: 2 to 4.5 mg/kg
Single Dose: 3.2 (3.25)
Frequency: 24 hourly
Route: IV
Instructions: For 10 Days, repeated per month
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Triazeno Imidazole. It belongs to Alkylating Agents pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Alkylating Agent pharmacological group.The Molecular Weight of Dacarbazine is 182.20. Its pKa is 4.4.
Contraindications
Dacarbazine
Effects
The severe or irreversible adverse effects of Dacarbazine, which give rise to further complications include Photosensitivity.Dacarbazine produces potentially life-threatening effects which include Hepatotoxicity, Moderate myelosuppression. which are responsible for the discontinuation of Dacarbazine therapy.The signs and symptoms that are produced after the acute overdosage of Dacarbazine include Severe myelosuppression.The symptomatic adverse reactions produced by Dacarbazine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Alopecia, Diarrhea, Fever, Myalgia, Malaise, Facial flushing, Facial paresthesia, Alopecia.
Indications
'Dacarbazine is primarily indicated in conditions like Hodgkin''s disease, Malignant melanoma, Metastatic melanoma, Metastatic melanoma, Metastatic melanoma, Metastatic melanoma, Neuroendocrine tumors, Soft tissue sarcoma.'
Interactions
Dacarbazine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementLevodopa These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store at room temperature or refrigerator. Protect from Sunlight. Use within 3 days (at4C) if refrigerated and within 8 hrs if kept at room temperature.
Warnings
Dacarbazine should be used with caution in patients with pre-existing blood disorders, liver disease or kidney disease, dental disease. It is classified as pregnancy category C and not recommended for use in pregnancy or lactation.
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