Doxylamine Succinate

Doxylamine succinate is an antihistamine commonly used as a nighttime sleep aid. This drug is also used to relieve symptoms of hay fever, allergic rhinitis, hives, rash or itching and other allergic reactions.


Adult Dose
Dose: 12.5 to 25 mg
Single Dose: 19 (18.75)
Frequency: 6 hourly
Route: oral
Instructions:
Neonatal
Paedriatic
Characteristics
Doxylamine Succinate also known as Doxylamine. . It is of Synthetic origin and belongs to Monoethanolamine derivative. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Doxylamine Succinate is 388.50.
Contraindications
Doxylamine Succinate is contraindicated in conditions like Hypersensitivity,Porphyria.
Effects
The severe or irreversible adverse effects of Doxylamine Succinate, which give rise to further complications include Convulsions, CNS depression, Blurred vision, Ventricular arrhythmia, Psychomotor impairment.The signs and symptoms that are produced after the acute overdosage of Doxylamine Succinate include Tachycardia, Ataxia, Tremor, Excitation, Psychosis.The symptomatic adverse reactions produced by Doxylamine Succinate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Nausea and vomiting, Lassitude, Incoordination.
Indications
Doxylamine Succinate is primarily indicated in conditions like Cold, Cough, Hypersensitivity reactions, Skin diseases, and can also be given in adjunctive therapy as an alternative drug of choice in Insomnia, Pruritus.
Interactions
No data regarding the interactions of Doxylamine Succinate was found.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store . Protect from Sunlight.
Warnings
Doxylamine succinate should be used with caution in prostatic hypertrophy, urinary retension, glaucoma and pyloro-duodenal obstruction. It should be used with care in hepatic disease and dose reduction may be necessary in renal impairment. Caution may be required in epilepsy. Children and elderly are more susceptible to side effects.
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