Cyproterone (Acetate)

Cyproterone (Acetate) is a hormone. Cyproterone (Acetate) is used in the treatment of prostate cancer, sexual disorders in male, hirsutism in women and acne etc.


Adult Dose
Dose: 100 mg
Single Dose: 100 (100)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Cyproterone (Acetate) also known as Androcur, Androcur, Androcur, Androcur. Cyprostat is the derivative of Cyproterone (Acetate). It is of Synthetic origin and belongs to Steroid. It belongs to Androgen antagonist pharmacological group on the basis of mechanism of action and also classified in Anti Allergic Agent pharmacological group.The Molecular Weight of Cyproterone (Acetate) is 416.90.
Contraindications
Cyproterone (Acetate) is contraindicated in conditions like Sickle cell anaemia,Liver diseases,Thromboembolism,Chronic depression.
Effects
The severe or irreversible adverse effects of Cyproterone (Acetate), which give rise to further complications include Azoospermia, Oligozoospermia.Cyproterone (Acetate) produces potentially life-threatening effects which include Jaundice, Hepatic failure. which are responsible for the discontinuation of Cyproterone (Acetate) therapy.The symptomatic adverse reactions produced by Cyproterone (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Fatigue, Gynecomastia, Decreased libido, Decreased LH, Decreased FSH, Increased prolactin, Negative nitrogen balance, Increased plasma triglycerides, Fall in fasting plasma glucose, Decreased LDL concentrations.
Indications
Cyproterone (Acetate) is primarily indicated in conditions like Androgenic acne, Androgenic alopecia, Flare with initial gonadorelin therapy, Hirsutism, Idiopathic precocious puberty, Inoperable prostatic carcinoma, Male hypersexuality, Male-female transsexualism, Prostate cancer (metastatic), flare with initial gonadorelin therapy, Prostate cancer (metastatic), hot flushes with gonadorelin therapy, Prostate cancer (metastatic), long-term palliative therapy, Prostate cancer, flare with initial gonadorelin therapy, Prostate cancer, hot flushes with gonadorelin therapy, Prostate cancer, long-term palliative therapy, Prostatic cancer.
Interactions
No data regarding the interactions of Cyproterone (Acetate) was found.
Interfrence
Artefactual increase in cortisol plasma levels by Fluorometry
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C.
Warnings
Avoid cyproterone in patients with liver disease or malignant or wasting disease, chronic depression, severe diabetes with vascular disease, sickle cell anemia or those with history of thrombo-embolic disorders. It should not be given to immature youths. In men treated with cyproterone, liver function should be monitored before treatment, if any sign or symptoms of hepatotoxicity occur then the treatment should be with drawn. In men with prostate cancer, it may be advisable to limit the duration of treatment. It should be used with caution during pregnancy.
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