Cyclopenthiazide

Cyclopenthiazide is a thiazide diuretic. It increases urination. Cyclopenthiazide is used in hypertention to lower the high blood pressure and also used to treat fluid overload.


Adult Dose
Dose: 0.004 to 0.014 mg/kg
Single Dose: 0.009 (0.009)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Benzothiadiazine. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.The Molecular Weight of Cyclopenthiazide is 379.90.
Contraindications
Cyclopenthiazide is contraindicated in conditions like Gout,Maturity onset diabetes.
Effects
The severe or irreversible adverse effects of Cyclopenthiazide, which give rise to further complications include Cholestatic jaundice, Impotence, Loss of libido.Cyclopenthiazide produces potentially life-threatening effects which include Blood dyscrasias, Hyponatremia, Hypokalemia, Stevens Johnson syndrome, Pancreatitis, Necrotizing vasculitis, Anaphylaxis, Vasculitis. which are responsible for the discontinuation of Cyclopenthiazide therapy.The symptomatic adverse reactions produced by Cyclopenthiazide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Volume depletion, Reduced uric acid urinary excretion, Glucose intolerance.
Indications
Cyclopenthiazide is primarily indicated in conditions like Diabetes insipidus, Edema, Heart failure, Hypercalciuric nephrolithiasis, Hypertension, Oedema.
Interactions
No data regarding the interactions of Cyclopenthiazide was found.
Interfrence
Benedicts Test for Urinary Reducing Substance
Risks
Drug should not be given to Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab
Warnings
It should be used with caution in patients with a history of hypersensitivity thiazide or related diuretics or sulfonamide and in patients with hepatic or hepatic disease.
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