Perazine Dimalonate

Perazine dimalonate is a phenothiazine with general properties similar to those of chlorpromazine and is used for the treatment of psychotic conditions. It has a piperazine side-chain.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Perazine Dimalonate is 547.60.
Contraindications
Perazine Dimalonate is contraindicated in conditions like Coma,CNS depression,Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Perazine Dimalonate, which give rise to further complications include Convulsions, Tachycardia, Cardiac arrhythmias, Anemia, Urticaria, Anemia, Hypotension, Tardive dyskinesia, Jaundice, Amenorrhea, Akathisia, Neuroleptic malignant syndrome, Anemia, Galactorrhea.The signs and symptoms that are produced after the acute overdosage of Perazine Dimalonate include Acute axonal neuropathies.The symptomatic adverse reactions produced by Perazine Dimalonate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Constipation, Dry mouth, Blurred vision, Weight gain, Miosis.
Indications
Perazine Dimalonate is primarily indicated in conditions like Psychotic illness.
Interactions
No data regarding the interactions of Perazine Dimalonate was found.
Interfrence
Abnormal LFTs
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Should be used with caution or not at all in patients with impaired liver, kidney, cardiovascular, cerebrovascular, and respiratory function and in those with angle-closure glaucoma, a history of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia, or urinary retention. Care is required in patients with epilepsy or a history of seizures as phenothiazines may lower the seizure threshold. Debilitated patients may be more prone to the adverse effects of phenothiazines as may the elderly, especially those with dementia. The sedative effects are most marked in the first few days of treatment; affected patients should not drive or operate machinery. Effects on the vomiting centre may mask the symptoms of overdosage of other drugs, or of disorders such as gastrointestinal obstruction. Use at extremes of temperature may be hazardous since body temperature regulation is impaired by phenothiazines. Should be used with caution in the presence of acute infection or leucopenia. Blood counts are advised if the patient develops an unexplained infection or fever.
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