Semustine

Semustine is a nitrosourea. It is one of group of antineoplastic drugs known as alkylating agent.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Semustine is 247.70.
Contraindications
Semustine is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Semustine, which give rise to further complications include Renal damage, Thrombocytopenia.The signs and symptoms that are produced after the acute overdosage of Semustine include Convulsions, Pulmonary fibrosis, Leucopenia, Optic neuritis.The symptomatic adverse reactions produced by Semustine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea and vomiting, Hyperpigmentation.
Indications
Semustine is primarily indicated in conditions like Brain tumors, Colorectal cancer, Lymphomas, Stomach cancer.
Interactions
No data regarding the interactions of Semustine was found.
Interfrence
Monitoring of renal functionMonitoring of liver enzymes
Risks
Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in a well closed container, . Protect from Sunlight and Heat.
Warnings
Used with caution in children who are at risk of severe delayed pul;monary toxicity, reduced lung function. Blood counts should be monitored weekly. Renal and hepatic functions should be monitored periodically.
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