Salsalate

Salsalate is a salicylic acid derivative that has analgesic,antiinflammatory and antipyretic actions.


Brands
Adult Dose
Dose: 3 g
Single Dose: 3 (3)
Frequency: As recommended.
Route: oral
Instructions:
Neonatal
Paedriatic
Characteristics
belongs to salicylic acid. . The Molecular Weight of Salsalate is 258.20.
Contraindications
Salsalate is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Salsalate, which give rise to further complications include Vomiting, Stomatitis, Hearing loss.The signs and symptoms that are produced after the acute overdosage of Salsalate include Nausea, Hallucinations, Headache.The symptomatic adverse reactions produced by Salsalate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Skin rash, Wheezing.
Indications
Salsalate is primarily indicated in conditions like Arthritic pain, Fever, Inflammation, Pain, and can also be given in adjunctive therapy as an alternative drug of choice in Osteoarthritis.
Interactions
Salsalate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinSalsalate, like aspirin, is converted to salicylic acid. Therefore, adding aspirin to salsalate can cause salicylic acid toxicity. GentamicinWhen Salsalate are combined with Gentamicin the blood levels of Gentamicin may increase, presumably because the elimination of Gentamicin is reduced. This may lead to side effects from Gentamicin.LithiumSalsalate may increase the blood levels of lithium by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity. MethotrexateWhen Salsalate are combined with methotrexate the blood levels of methotrexate may increase, presumably because the elimination of methotrexate is reduced. This may lead to side effects from methotrexate.Vortioxetineeither increases effects of other by anticoagulationmoniotr closely These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container, at room temperature. Protect from Moisture and Heat.
Warnings
'Children and teenager may not use this drug if they have chicken pox,influenza because reye''s syndrome may occur. Salsalate should be used in pregnancy when clearly needed. This drug may cause stomach bleeding so care should be taken. Take Salsalate with food,milk or antacid. Avoid alcohol.'
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