Oxyphenbutazone

Oxyphenbutazone, a metabolite of phenylbutazone, is an NSAID. It has been applied topically to the eye as an anti-inflammatory ointment in conditions such as episcleritis. Oxyphenbutazone was used systemically in disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe haematological adverse effects.

Brands
Adult Dose
Dose: 2 to 4.5 mg/kg
Single Dose: 3.2 (3.25)
Frequency: As recommended.
Route: IV
Instructions:
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Oxyphenbutazone is 401.40.
Contraindications
Oxyphenbutazone is contraindicated in conditions like Peptic ulcer,Blood dyscrasias,Congestive heart failure,Hepatitis.
Effects
The severe or irreversible adverse effects of Oxyphenbutazone, which give rise to further complications include Allergic reactions, Abdominal pain, Blurred vision.The symptomatic adverse reactions produced by Oxyphenbutazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Headache, Drowsiness, Irritability, Diarrhea, Heart burn, Bruising, Weight loss, Loss of appetite.
Indications
Oxyphenbutazone is primarily indicated in conditions like Fever, Gout, Osteoarthritis, Pain, Rheumatoid arthritis.
Interactions
No data regarding the interactions of Oxyphenbutazone was found.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tablets Store at room temperature. Protect from Sunlight and Moisture. Parentrals Store at room temperature. Protect from Moisture.
Warnings
Oxyphenbutazone should be used with caution in patients with incipient cardiac failure, blood dyscrasias, pancreatitis, kidney or liver diseases, gastrointestinal (GI) inflammation.patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness. It should not be given intramuscularly or injected in any place other than a vein, as it can cause tissue damage. Tissue damage and edema may also occur if the drug is injected repetitively into the same vein.
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