Norethandrolone

Norethandrolone is an anabolic steroid . It is given by mouth in the treatment of aplastic anaemia.


Brands
Adult Dose
Dose: 0.2 to 2 mg/kg
Single Dose: 1.1 (1.1)
Frequency: As recommended.
Route: PO
Instructions: Daily
Neonatal
Paedriatic
Characteristics
Norethandrolone also known as Ethylnortestosterone. . It is of Synthetic origin. . The Molecular Weight of Norethandrolone is 302.45.
Contraindications
Norethandrolone is contraindicated in conditions like Breast cancer,Cardiovascular disease,Pregnancy,Prostate cancer,Breast feeding.
Effects
The severe or irreversible adverse effects of Norethandrolone, which give rise to further complications include Hepatotoxicity, Hepatotoxicity.The signs and symptoms that are produced after the acute overdosage of Norethandrolone include Nausea, Hepatic damage, Prostate carcinoma, Jaundice, GI disturbances, Cardiovascular disturbances, Psychiatric disturbances, Myocardial infarction, Stroke, Muscular hypertrophy.The symptomatic adverse reactions produced by Norethandrolone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Impotence, Weight gain, Fluid retention, Virilization, GI bleeding, Azoospermia.
Indications
Norethandrolone is primarily indicated in conditions like Aplastic anemia, Contraception, Endometriosis.
Interactions
Norethandrolone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementTegaserodTegaserod decreased Norethandrolone plasma concentrations by less than 10% in a clinical study with a low-dose triphasic oral contraceptive (n=45). The mechanism is unknown. There were no changes in ethinyl estradiol concentrations or in contraceptive efficacy. No action is necessary.Minor These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 15°C-30°C. Protect from Sunlight.
Warnings
Norethandrolone should be used with extreme care in children because of the masculinising effects and also because premature closure of the epiphyses may occur resulting in inhibited linear growth and small stature. Skeletal maturation should be monitored during therapy. Norethandrolone should be used cautiously in patients with cardiovascular disorders, renal or hepatic impairment, epilepsy, migraine, diabetes mellitus or other conditions which may be aggravated by the possible fluid retention or oedema caused. They should not be given to patients with hypercalcaemia or hypercalciuria, and should be used cautiously in conditions in which there is a risk of these developing such as skeletal metastases. Norethandroloneshould not be given during pregnancy because of the risk of virilisation of the female fetus.
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