Cortisone (Acetate)

Cortisone (Acetate) is ester of cortisone, which is a natural glucocorticoid with a slight degree of mineralocoricoid activity. Chemically Cortisone (Acetate) is identified as 17, 21-Dihydroxypregn-4-ene-3, 11, 20-trione 21-acetate. It has slow onset but long duration of action. Cortisone (Acetate) is effective as an anti-infalmmatory and immunosuppressant in a wide variety of disorders. Administered orally or intramuscularly.

Brands
Adult Dose
Dose: 0.179 to 0.267 mg/kg
Single Dose: 0.22 (0.223)
Frequency: 12 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Dose: 0.33 mg/kg
Single Dose: 0.33 (0.33)
Frequency: 8 hourly
Route: Oral
Instructions: showrly disorders
Characteristics
. It is of Synthetic origin and belongs to Steroidal Hormone. It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Corticosteroid Adrenal pharmacological group.The Molecular Weight of Cortisone (Acetate) is 402.50.
Contraindications
Cortisone (Acetate)
Effects
The severe or irreversible adverse effects of Cortisone (Acetate), which give rise to further complications include Glaucoma, Pancreatitis, Hypertension, Muscle wasting, Diabetes, Osteoporosis, Skeletal deformation, Fracture, Avascular necrosis of bone, Psychosis, Depression, Posterior subcapsular cataract, Increased intracranial pressure, Immune suppression, Supression of hypothalamic-pituitary-adrenal system, Increased IOP (intraocular pressure), Inflammatory response suppression.The symptomatic adverse reactions produced by Cortisone (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Edema, Moon face, Striae, Bruising, Acne, Hirsutism, Body fat deposition.
Indications
Cortisone (Acetate) is primarily indicated in conditions like Adrenocortical insufficiency, Congenital adrenal hyperplasia, and can also be given in adjunctive therapy as an alternative drug of choice in Diarrhoea, Inflammation.
Interactions
Cortisone (Acetate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlfacalcidolreverse hypercalcemia induced by alfacalcidolCarbamazepineCarbamazepine accelerates metabolism of Corticosteroids (reduced effect).NatamycinConcurrent use may increase the toxicity, therefore concomitant use is contraindicated. NateglinideConcurrent use may reduce the hypoglycemic action of Nateglinide.OxandroloneThe concomitant administration of oxandrolone and adrenal cortical steroids may increase the edema in patients with edema. The mechanism and clinical significance are unknown. Closer monitoring may be appropriate, especially in patients with conditions that may be aggravated by fluid retention.MinorPhenytoin (Na)PrimidoneRifampicinRitodrine (HCl)Corticosteroids are often used concurrently to enhance fetal lung maturity. Intravenous ritodrine and, to a lesser extent, corticosteroids each expand plasma volume by causing sodium retention. SermorelinConcomitant Cortisone (Acetate) therapy may inhibit the response to Sermorelin. Sodium ChlorideCaution must be exercised in the administration of Sodium Chloride Injection Cortisone (Acetate).SomatropinSomatropin administration may alter the clearance of Cortisone (Acetate). These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
React with FeCl3 in measuring serum cholesterol
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Inj Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Cortisone acetate should be used with caution in patients with liver, kidney, heart or intestinal disease, hypothyroidism, high blood pressure, myasthenia gravis, osteoporosis (brittle bones), herpes eye infection or a history of tuberculosis (TB), seizures, ulcers, or blood clots and of any drug allergies. Do not have a vaccination, other immunization or any skin test while using cortisone, unless specifically recommended. It should be used with caution while taking aspirin, arthritis medicines or alcohol because; cortisones may make stomach and intestines more susceptible to the irritating effects of alcohol, aspirin and certain arthritis medications increasing the risk of ulcers. Report any injuries or signs of infection (fever, sore throat, pain during urination and muscle aches) that occur during treatment and within 12 months after treatment with cortisone, dose may need to be adjusted or may need to start taking the drug again. It should be used with extreme caution in diabetic patients because this drug may increase blood sugar level. Test urine for sugar (glucose) and contact the doctor if sugar is present in urine. Dose of diabetes medication and diet may need to be changed. This medication should be used only when clearly needed during pregnancy or lactation. Avoid use in infants because this medication can cause growth suppression in infants.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.