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Dose: 75 mg
Single Dose: 75 (75)
Frequency: 24 hourly
Route: PO
Instructions:

Clopidogrel (Bisulphate) is the derivative of Clopidogrel. It is of Synthetic origin and belongs to Ticlopidine. . The Molecular Weight of Clopidogrel is 419.90.

Clopidogrel is contraindicated in conditions like Peptic ulcer,Intracranial hemorrhage,Hypersensitivity.

The severe or irreversible adverse effects of Clopidogrel, which give rise to further complications include Hepatitis, Oedema.The signs and symptoms that are produced after the acute overdosage of Clopidogrel include BLood dyscrasias.The symptomatic adverse reactions produced by Clopidogrel are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Nausea, Diarrhea, Abdominal pain, Rashes, Skin RashX, Dyspepsia, Depression, Arthralgia, Influenza like syndrome, Chest pain, GI disturbance, Epistaxis.

Clopidogrel is primarily indicated in conditions like Atherosclerosis, Myocardial infarction, Myocardial infarction prophylaxis, Peripheral arterial disease, Prophylaxis for NSAID-associated gastric and duodenal ulcers, Stroke, Stroke prophylaxis, Thrombo-embolic complications, and can also be given in adjunctive therapy as an alternative drug of choice in Angina, Unstable angina.

Clopidogrel is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAescinAluminium Hydroxide and OxideAluminium Hydroxide and Oxide do not appear to affect serum concentration of Clopidogrel. N/ANo action required.Cerivastatin SodiumCerivastatin sodium has its toxicity increased by clopidrogelCilostazoleCimetidine (HCl)Dabigatranclopidogrel increases the AUC and Cmax of dabigatran by approximately 30 and 40% respectively, and thereby increases the risk of bleeding.EsomeprazoleLornoxicamMay prolong the bleeding time (increased risk of bleeding)Nadroparin (Ca)Concurrent use may increase the risk of hemorrhage.NicoumaloneOligomeric ProcyanidinConcurrent use of high doses of OPCs with Clopidogrel might cause a risk of excessive bleeding. OmeprazolePantoprazolePantoprazole may decrease the effectiveness of Clopidogrel.Phenytoin (Na)Rivaroxabanclopidogrel is a platelet aggregating inhibitor,may increase bleeding timeSilymarinSilymarin may interfere with Clopidogrel because both drugs are broken down by the same liver enzymes.TenecteplaseConcurrent use is usually not recommended but may be required in some cases. If both medicines are prescribed together, change of dose may be required.TheophyllineTiaprofenic AcidClopidogrel can cause an increased risk of bleeding. Tinzaparin SodiumConcurrent use may increase the risk of bleeding.If coadministration is essential, close clinical and laboratory monitoring of these patients is advised.Warfarin (Na)Clopidogrel does not appear to alter the pharmacodynamic effect(s) of Warfarin. Clopidogrel does not appear to affect serum concentration of Warfarin.N/ANo action required. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, and Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Store at room temperature, . Protect from Sunlight and Heat.

Use with caution in patients recieving other drugs that increase risk of bleeding including anticogulants,platelets and NSAIDS. It should be used with extreme caution in patients with history of bleeding disorder, or who may be at risk of increased bleeding from trauma, surgery or other pathalogical conditions, and patients with ulcers, liver problems or low blood count. If a patient is to undergo elective surgery and an antiplatelet effect is not desired, clopidrogel should be discontinued 7 days prior to surgery. It is classified as pregnancy category B and should be used with caution during pregnancy or lactation.