Colistin (Sulphate & Sulphomethate Na)

Colistin (Sulphate and Sulphomethate Na) is antibiotic and is used to treat bacterial infections. Colistin is marketed only for oral administration in the treatment of intestinal infections. Colistin (Sulphate and Sulphomethate Na) is also used topically in the treatment of some external ear infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed. Colistin (Sulphate and Sulphomethate Na) is important to take the drug for the full time period as prescribed. If you discontinue the drug it may result in ineffective treatment.

Brands
COLIJECT COLIJECT
Adult Dose
Dose: 0.833 to 1.666 mg/kg
Single Dose: 1.2 (1.2495)
Frequency: 8 hourly
Route: IM
Instructions: -
Neonatal
Dose: 0.031 million units/kg
Single Dose: 0.031 (0.031)
Frequency: 8 hourly
Route: oral
Instructions: single dose 0.093
Paedriatic
Dose: 0.025 to 0.05 millionunits/kg
Single Dose: 0.038 (0.0375)
Frequency: 8 hourly
Route: Oral
Instructions: single dose 0.74
Characteristics
. It is of Natural origin and belongs to Polymyxin. It belongs to Antibiotic (Cell Wall) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Colistin (Sulphate & Sulphomethate Na) is 1170.00. Its pKa is at 25 degree centigrade 12.1.
Contraindications
Colistin (Sulphate & Sulphomethate Na) is contraindicated in conditions like Myasthenia gravis,Pregnancy,Breast feeding.
Effects
The severe or irreversible adverse effects of Colistin (Sulphate & Sulphomethate Na), which give rise to further complications include kidney dysfunction.Colistin (Sulphate & Sulphomethate Na) produces potentially life-threatening effects which include Nephrotoxicity, Neurotoxicity. which are responsible for the discontinuation of Colistin (Sulphate & Sulphomethate Na) therapy.The signs and symptoms that are produced after the acute overdosage of Colistin (Sulphate & Sulphomethate Na) include Apnea, Renal insufficiency, Muscle weakness.The symptomatic adverse reactions produced by Colistin (Sulphate & Sulphomethate Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Vomiting, Fever, Confusion, Urticaria, Peripheral neuropathy, Circumoral paresthesia, Respiratory insufficiency, Muscular weakness, Confusion, dizziness.
Indications
Colistin (Sulphate & Sulphomethate Na) is primarily indicated in conditions like Benign gastric and duodenal ulcers, Bladder irrigation, Bowel sterilization, Decontamination of digestive tract, GI infections, Metastatic germ cell cancer, Oedema, Oliguria due to renal failure, Respiratory tract infections, Superficial infections, Systemic infections, and can also be given in adjunctive therapy as an alternative drug of choice in Cystic fibrosis.
Interactions
Colistin (Sulphate & Sulphomethate Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCapreomycinIncreased risk of nephrotoxicity when capreomycin given with colistin.ChloramphenicolDistigmine (Br)ErythromycinFloxacillin (Na)NeostigminePyridostigmine (Br)RivastigmineTrimethoprim These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Tests for estimating urinary amino acids.
Risks
Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Syrup Store Below 25°C. Protect from Sunlight.
Warnings
Renal impairment; porphyria; risk of bronchospasmon inhalation---may be prevented or treated with a selective beta2 agonist. Colistin should be used with caution in patients who are sensitive to aminoglycosides.Take appropriate measures in case of secondry infections.
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