Methicillin Sodium

Methicillin Sodium is a narrow spectrum beta-lactam antibiotic. It was previously used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins, but is no longer clinically used. Its role in therapy has been largely replaced by flucloxacillin and dicloxacillin, however the term methicillin-resistant Staphylococcus aureus (MRSA) continues to be used to describe Staphylococcus aureus strains resistant to all penicillins.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Semi Synthetic origin. It belongs to Penicillinase-sensitive Penicillin pharmacological group.The Molecular Weight of Methicillin Sodium is 420.40.
Contraindications
Methicillin Sodium is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Methicillin Sodium, which give rise to further complications include Hemolytic anemia, Hemolytic anemia, Neutropenia, Acute interstitial nephritis, Hemolytic anemia.Methicillin Sodium produces potentially life-threatening effects which include Encephalopathy, Anaphylaxis. which are responsible for the discontinuation of Methicillin Sodium therapy.The signs and symptoms that are produced after the acute overdosage of Methicillin Sodium include Jaundice, Hepatitis, Nephropathy, Nephritis.The symptomatic adverse reactions produced by Methicillin Sodium are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Skin rashes, Pseudomembranous colitis, Hypersensitivity reactions, Skin rashes.
Indications
Methicillin Sodium is primarily indicated in conditions like Staphlococcal infections.
Interactions
No data regarding the interactions of Methicillin Sodium was found.
Interfrence
Thyroid Function Test
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Patients known to be hypersensitive to penicillins should be given an antibacterial of another class. However, sensitised patients may also react to the cephalosporins and other beta lactams. Penicillins should be given with caution to patients with a history of allergy, especially to drugs. Skin contact with penicillins should be avoided since sensitisation may occur. Penicillin therapy changes the normal bacterial flora and can lead to supra-infection with penicillin-resistant organisms including Clostridium difficile or Candida, particularly with prolonged use. Care is necessary if very high doses of penicillins are given, especially if renal function is poor, because of the risk of neurotoxicity.
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